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2027

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Best of South America with Amazon Cruise Santiago → Iquitos (2026)

22 days
From Santiago to Iquitos
4.1
26 traveler reviews

No departure dates available

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Plan your adventure:
Explorer
Curated to ignite your sense of adventure
Fully Guided
An experienced guide will be with you for the entire tour
Medium Intensity
Travelers should be comfortable with somewhat-demanding activities
Guided in English
Group Size 1 - 200
Ages 8+
Image of a map showing the route of the tour

Itinerary

  1. Day 1

    Santiago

    Meals
    Dinner (Welcome dinner)
    Accommodation
    Hotel (Santiago)

    Included Activities

    • Welcome dinner
    Itinerary Image 1
  2. Day 2

    Santiago

    Accommodation
    Hotel (Santiago)

    Included Activities

    • Guided discovery of Santiago

    Optional Activities

    • Dinner at Liguria Lastarria - traditional Chilean cuisine including empanadas, tuna tartar, and Chilean-style pichanga
    • Dinner at Ambrosia - Chilean and French fusion cuisine including ceviche
    Landmarks
    Andes Mountains
    Pacific Ocean
  3. Day 3

    Santiago - Valpara\u00edso

    Meals
    Lunch (Lunch at a local vineyard)
    Accommodation
    Hotel (Santiago)

    Included Activities

    • Guided discovery of Valpara\u00edso historic quarter
    • Valpara\u00edso Funicular Ride
    • Lunch at a local vineyard
    Landmarks
    Valpara\u00edso Historic Quarter
    Valpara\u00edso Funicular
  4. Day 4

    Santiago to Buenos Aires

    Meals
    Dinner (Tango demonstration and tapas)
    Accommodation
    Hotel (Buenos Aires)

    Included Activities

    • Tango demonstration and tapas
    Landmarks
    Recoleta
    Itinerary Image 1
  5. Day 5

    Buenos Aires

    Accommodation
    Hotel (Buenos Aires)

    Included Activities

    • Guided discovery of La Boca neighborhood
    • Guided exploration of Palermo neighborhood
    • Visit to La Recoleta Cemetery

    Optional Activities

    • Dinner at Fogon Asado - South American barbecued meats
    • Dinner at Fervor - Old-world steakhouse with Argentine cuisine featuring grilled meats and seafood
    • Dinner and Tango Show - Argentine dishes accompanied by a passionate tango show
    Landmarks
    La Boca
    Palermo
    La Recoleta Cemetery
  6. Day 6

    Buenos Aires

    Accommodation
    Hotel (Buenos Aires)

    Optional Activities

    • Tigre Cruise - cruise over the rivers and canals of the Paraná Delta
    • Parisian Walking Tour - discover Plaza San Martin, Plazoleta Pellegrini and the Parisian character of Buenos Aires
    • Teatro Colón Tour - guided tour of the iconic opera house and Buenos Aires' high-arts scene
    Landmarks
    Teatro Colón
    Plaza San Martin
    Paraná Delta
  7. Day 7

    Buenos Aires to Iguazú Falls

    Accommodation
    Hotel (Iguazú Falls)

    Included Activities

    • Rainforest Ecological Train experience
    • Viewing points including Devil's Throat
    Landmarks
    Iguazú Falls
    Devil's Throat
    Iguazú National Park
    Itinerary Image 1
  8. Day 8

    Iguazú Falls

    Meals
    Dinner (Wine tasting with cheese pairings)
    Accommodation
    Hotel (Iguazú Falls)

    Included Activities

    • Leisurely walks on Brazilian side viewing platforms
    • Wine tasting and cheese pairings at Gran Melia Iguazú

    Optional Activities

    • Jet Boat Safari - Close-up experience of Iguazú Falls' roaring cascades
    • Helicopter Ride - Scenic aerial views of Iguazú Falls
    Landmarks
    Iguazú Falls
  9. Day 9

    Iguazú Falls to Rio de Janeiro

    Meals
    Dinner (Dinner at hotel)
    Accommodation
    Hotel (Copacabana Palace)
    Landmarks
    Copacabana Beach
    Itinerary Image 1
  10. Day 10

    Rio de Janeiro

    Meals
    Lunch (Brazilian barbecue at local restaurant)
    Accommodation
    Hotel (Copacabana Palace)

    Included Activities

    • Visit to Corcovado and Christ the Redeemer statue with panoramic views
    • Lunch at local restaurant with Brazilian barbecue
    • Cable car to Sugarloaf Mountain summit for sunset and drinks
    Landmarks
    Corcovado
    Christ the Redeemer
    Sugarloaf Mountain
  11. Day 11

    Rio de Janeiro

    Accommodation
    Hotel (Copacabana Palace)

    Included Activities

    • Freedom of Choice sightseeing activity - either Jeep Tour of Tijuca National Park or Guanabara Bay Boat Tour
    Landmarks
    Tijuca National Park
    Guanabara Bay
  12. Day 12

    Rio de Janeiro to Lima

    Meals
    Lunch (Lunch at Café del Museo)
    Accommodation
    Hotel (Country Club Lima Hotel), Hotel (InterContinental Real Lima Miraflores)

    Included Activities

    • Lunch at Café del Museo
    • Visit to Larco Museum
    Landmarks
    Larco Museum
    Itinerary Image 1
  13. Day 13

    Lima

    Meals
    Lunch (Traditional South American fare at private hacienda)
    Accommodation
    Hotel (Country Club Lima Hotel), Hotel (InterContinental Real Lima Miraflores)

    Included Activities

    • Guided discovery of Lima's World Heritage-listed historic centre
    • Lunch at private hacienda with traditional South American fare
    • Peruvian Paso horse show
    • Visit to ruins of Pachacamac
    Landmarks
    Lima Historic Centre
    Pachacamac
  14. Day 14

    Lima to Sacred Valley

    Meals
    Lunch (Farm-to-table lunch at working corn farm)
    Accommodation
    Hotel (Explora Sacred Valley)

    Included Activities

    • Flight to Cusco
    • Visit to working corn farm at Hacienda Sarapampa
    • Farm-to-table lunch at Hacienda Sarapampa
    Landmarks
    Cusco
    Sacred Valley
    Itinerary Image 1
  15. Day 15

    Sacred Valley

    Meals
    Lunch (Traditional lunch with Andes mountains and surrounding valleys views), Dinner (Dinner at hotel)
    Accommodation
    Hotel (Explora Sacred Valley)

    Included Activities

    • Welcome by local Misminay community
    • Traditional weaving demonstration
    • Traditional lunch with Andes views
    • Visit to Salt Mines of Maras
    • Visit to Moray archaeological site with Incan circular terraces
    • Guided exploration of Sacred Valley
    Landmarks
    Misminay Community
    Salt Mines of Maras
    Moray
    Andes Mountains
    Itinerary Image 1
  16. Day 16

    Sacred Valley to Aguas Calientes

    Meals
    Lunch (Gourmet Andean-inspired lunch on Inca Rail First Class train), Dinner (Dinner at hotel)
    Accommodation
    Hotel (Sumaq Machu Picchu Hotel)

    Included Activities

    • Inca Rail First Class Machu Picchu Train
    • Gourmet Andean-inspired lunch on board train
    Landmarks
    Aguas Calientes
  17. Day 17

    Aguas Calientes to Cusco

    Accommodation
    Hotel (Cusco)

    Included Activities

    • Locally guided exploration of Machu Picchu
    • PeruRail Vistadome Machu Picchu Train return journey
    Landmarks
    Machu Picchu
    Itinerary Image 1
  18. Day 18

    Cusco

    Meals
    Dinner (Dinner at MAP Café in the central courtyard of the Museum of Pre-Columbian Art)
    Accommodation
    Hotel (Cusco)

    Included Activities

    • Guided discovery of Cusco
    • Visit to Plaza de Armas

    Optional Activities

    • Peruvian Cooking Class - Learn to prepare traditional Peruvian dishes and discover traditional ingredients
    • Sacsayhuamán Citadel Visit - Explore the 15th-century dry stone archaeological site
    Landmarks
    Plaza de Armas
    Sacsayhuamán
    Museum of Pre-Columbian Art
  19. Day 19

    Cusco to Amazon (Iquitos)

    Meals
    Lunch (Boxed lunch en route to Nauta), Dinner (Three-course dinner on board Delfin III)
    Accommodation
    Hotel (Amazon River)

    Included Activities

    • Coach transfer through rainforest with commentary
    • Skiff exploration along Marañón River at dusk
    • Three-course dinner on board Delfin III
    Landmarks
    Iquitos
    Peruvian Amazon
    Marañón River
    Itinerary Image 1
  20. Day 20

    Amazon River Cruise

    Meals
    Lunch (Lunch on board Delfin III)
    Accommodation
    Hotel (Amazon River)

    Included Activities

    • Meeting with local Shaman to learn about rainforest plants and medicine
    • Kayaking along tributary tributaries
    Landmarks
    Peruvian Amazon
  21. Day 21

    Amazon River

    Meals
    Breakfast, Lunch, Dinner
    Accommodation
    Hotel (Amazon River)

    Included Activities

    • Skiff fishing trip on Nauta Cañó
    • Wildlife viewing including piranha spotting
    • Local community visit and cultural exchange
    • Rainforest trail walk at Nauta Cañó
    • Guided viewing of Marañón and Ucayali rivers confluence
    Landmarks
    Nauta Cañó
    Marañón River
    Ucayali River
    Amazon River
  22. Day 22

    Amazon to Iquitos

    Included Activities

    • Visit to Tropical Amazon Aquarium
    Landmarks
    Tropical Amazon Aquarium
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What's Included

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  • Accommodation
  • Flights
  • Guide
  • Meals
  • Additional Services
  • Transport

What's Not Included

  • Insurance
  • Optional
  • Additional Services

Where You'll Stay

All accommodations are subject to change

Operated by

APT

Number of tours

189

Age Range

8 to 99 years old

Response time

within 3 days

Response rate

57%

A family-owned company since its conception in the 1920s. APT had its...

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Your Peace of Mind Options

Cancellation Policy

A transparent overview of applicable fees.

Travel Insurance

Be covered for any unforseen circumstances.

Reviews About This Operator

Dates & Availability

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2026

Jan
Feb
Mar
Apr
May
Jun
Jul
Aug
Sep
Oct
Nov
Dec

2027

Jan
Feb
Mar
Apr
May
Jun
Jul
Aug
Sep
Oct
Nov
Dec

2028

Jan
Feb
Mar
Apr
May
Jun
Jul
Aug
Sep
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1 Adult2 Adults, 1 Child2 Children

Who is travelling?

AdultsAges 18 or above

2

ChildrenUnder 18

0
Upcoming departures
  • From Tuesday
    21 Jul, 2026
    To Tuesday
    11 Aug, 2026
    Not available in your region
  • From Tuesday
    29 Sep, 2026
    To Tuesday
    20 Oct, 2026
    Not available in your region
  • From Tuesday
    6 Oct, 2026
    To Tuesday
    27 Oct, 2026
    Not available in your region
  • 2 Other Unavailable Departures
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Plan your adventure:

Good to Know

Tour ID: 307089

  • Currencies
    $
    Argentine Peso
    Argentina
    R$
    Brazilian Real
    Brazil
    $
    Chilean Peso
    Chile
    S/.
    Sol
    Peru
  • Plugs & Adapters

    As a traveler from USA, Canada, England, South Africa you will need an adaptor for types I, L. As a traveler from Australia, New Zealand you will need an adaptor for type L.

    Type I
    Argentina
    Type L
    Chile
  • Vaccines
    • These are only indications, so please visit your doctor before you travel to be 100% sure.
    • Typhoid - Recommended for Argentina.Brazil.Chile.Peru. Ideally 2 weeks before travel.
    • Hepatitis A - Recommended for Argentina.Brazil.Chile.Peru. Ideally 2 weeks before travel.
    • Hepatitis B - Recommended for Argentina.Brazil.Chile.Peru. Ideally 2 months before travel.
    • Rabies - Recommended for Argentina.Chile.Peru. Ideally 1 month before travel.
    • Yellow fever - Recommended for Argentina.Brazil.Peru. Ideally 10 days before travel.
    • Tuberculosis - Recommended for Brazil.Peru. Ideally 3 months before travel.
  • Visa
    • Unfortunately we cannot offer you a visa application service. Whether you need a visa or not depends on your nationality and where you wish to travel. Assuming your home country does not have a visa agreement with the country you're planning to visit, you will need to apply for a visa in advance of your scheduled departure.
    • Here is an indication for which countries you might need a visa. Please contact the local embassy for help applying for visas to these places.
  • Payment information
    • For any tour departing before July 10th, 2026 a full payment is necessary. For tours departing after July 10th, 2026, a minimum payment of $750 is required to confirm your booking with APT. The final payment will be automatically charged to your credit card on the designated due date. The final payment of the remaining balance is required at least 120 days prior to the departure date of your tour. TourRadar never charges you a booking fee and will charge you in the stated currency.
    • The following cards are accepted for "APT" tours: Visa, Maestro, Mastercard, American Express or PayPal. TourRadar does NOT charge you an extra fee for using any of these payment methods.
  • Cancellation Policy
  • Accessibility
    Some tours are not suitable for mobility-restricted traveler, however, some operators may be able to accommodate special requests. For any enquiries, you can contact our customer support team, who are ready and waiting to help you.

Who is travelling?

AdultsAges 18 or above

2

ChildrenUnder 18

0

Select departure month

2026

Jan
Feb
Mar
Apr
May
Jun
Jul
Aug
Sep
Oct
Nov
Dec

2027

Jan
Feb
Mar
Apr
May
Jun
Jul
Aug
Sep
Oct
Nov
Dec

2028

Jan
Feb
Mar
Apr
May
Jun
Jul
Aug
Sep
Oct
Nov
Dec