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Best of South America with Amazon Cruise 2026 - Santiago to Iquitos, 2027/28 - Rio de Janeiro to Iquitos (2026)

22 days
•
From Santiago to Iquitos
4.2 (27 reviews)

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Plan your adventure:
Ancient Wonders
Walk among ruins, temples, and timeless landmarks
Fully Guided
An experienced guide will be with you for the entire tour
Medium Intensity
Travelers should be comfortable with somewhat-demanding activities
Guided in English
Group Size 1 - 200
Ages 8+
Image of a map showing the route of the tour

Itinerary

  1. Intro

    Introduction

  2. Day 1

    Santiago

    Santiago
    Meals
    Dinner (Welcome dinner)
    Accommodation
    Hotel (Santiago)

    Included Activities

    • Welcome dinner
    Itinerary Image 1
  3. Day 2

    Santiago

    Santiago
    Accommodation
    Hotel (Santiago)

    Included Activities

    • Guided discovery of Santiago

    Optional Activities

    • Dinner at Liguria Lastarria - traditional Chilean cuisine including empanadas, tuna tartar, and Chilean-style pichanga
    • Dinner at Ambrosia - Chilean and French fusion cuisine including ceviche
    Landmarks
    Andes Mountains
    Pacific Ocean
  4. Day 3

    Santiago - Valpara\u00edso

    Santiago - Valpara\u00edso
    Meals
    Lunch (Lunch at a local vineyard)
    Accommodation
    Hotel (Santiago)

    Included Activities

    • Guided discovery of Valpara\u00edso historic quarter
    • Valpara\u00edso Funicular Ride
    • Lunch at a local vineyard
    Landmarks
    Valpara\u00edso Historic Quarter
    Valpara\u00edso Funicular
  5. Day 4

    Santiago to Buenos Aires

    Santiago to Buenos Aires
    Meals
    Dinner (Tango demonstration and tapas)
    Accommodation
    Hotel (Buenos Aires)

    Included Activities

    • Tango demonstration and tapas
    Landmarks
    Recoleta
    Itinerary Image 1
  6. Day 5

    Buenos Aires

    Buenos Aires
    Accommodation
    Hotel (Buenos Aires)

    Included Activities

    • Guided discovery of La Boca neighborhood
    • Guided exploration of Palermo neighborhood
    • Visit to La Recoleta Cemetery

    Optional Activities

    • Dinner at Fogon Asado - South American barbecued meats
    • Dinner at Fervor - Old-world steakhouse with Argentine cuisine featuring grilled meats and seafood
    • Dinner and Tango Show - Argentine dishes accompanied by a passionate tango show
    Landmarks
    La Boca
    Palermo
    La Recoleta Cemetery
  7. Day 6

    Buenos Aires

    Buenos Aires
    Accommodation
    Hotel (Buenos Aires)

    Optional Activities

    • Tigre Cruise - cruise over the rivers and canals of the Paraná Delta
    • Parisian Walking Tour - discover Plaza San Martin, Plazoleta Pellegrini and the Parisian character of Buenos Aires
    • Teatro Colón Tour - guided tour of the iconic opera house and Buenos Aires' high-arts scene
    Landmarks
    Teatro Colón
    Plaza San Martin
    Paraná Delta
  8. Day 7

    Buenos Aires to Iguazú Falls

    Buenos Aires to Iguazú Falls
    Accommodation
    Hotel (Iguazú Falls)

    Included Activities

    • Rainforest Ecological Train experience
    • Viewing points including Devil's Throat
    Landmarks
    Iguazú Falls
    Devil's Throat
    Iguazú National Park
    Itinerary Image 1
  9. Day 8

    Iguazú Falls

    Iguazú Falls
    Meals
    Dinner (Wine tasting with cheese pairings)
    Accommodation
    Hotel (Iguazú Falls)

    Included Activities

    • Leisurely walks on Brazilian side viewing platforms
    • Wine tasting and cheese pairings at Gran Melia Iguazú

    Optional Activities

    • Jet Boat Safari - Close-up experience of Iguazú Falls' roaring cascades
    • Helicopter Ride - Scenic aerial views of Iguazú Falls
    Landmarks
    Iguazú Falls
  10. Day 9

    Iguazú Falls to Rio de Janeiro

    Iguazú Falls to Rio de Janeiro
    Meals
    Dinner (Dinner at hotel)
    Accommodation
    Hotel (Copacabana Palace)
    Landmarks
    Copacabana Beach
    Itinerary Image 1
  11. Day 10

    Rio de Janeiro

    Rio de Janeiro
    Meals
    Lunch (Brazilian barbecue at local restaurant)
    Accommodation
    Hotel (Copacabana Palace)

    Included Activities

    • Visit to Corcovado and Christ the Redeemer statue with panoramic views
    • Lunch at local restaurant with Brazilian barbecue
    • Cable car to Sugarloaf Mountain summit for sunset and drinks
    Landmarks
    Corcovado
    Christ the Redeemer
    Sugarloaf Mountain
  12. Day 11

    Rio de Janeiro

    Rio de Janeiro
    Accommodation
    Hotel (Copacabana Palace)

    Included Activities

    • Freedom of Choice sightseeing activity - either Jeep Tour of Tijuca National Park or Guanabara Bay Boat Tour
    Landmarks
    Tijuca National Park
    Guanabara Bay
  13. Day 12

    Rio de Janeiro to Lima

    Rio de Janeiro to Lima
    Meals
    Lunch (Lunch at Café del Museo)
    Accommodation
    Hotel (InterContinental Real Lima Miraflores)

    Included Activities

    • Lunch at Café del Museo
    • Visit to Larco Museum
    Landmarks
    Larco Museum
    Itinerary Image 1
  14. Day 13

    Lima

    Lima
    Meals
    Lunch (Traditional South American fare at private hacienda)
    Accommodation
    Hotel (InterContinental Real Lima Miraflores)

    Included Activities

    • Guided discovery of Lima's World Heritage-listed historic centre
    • Lunch at private hacienda with traditional South American fare
    • Peruvian Paso horse show
    • Visit to ruins of Pachacamac
    Landmarks
    Lima Historic Centre
    Pachacamac
  15. Day 14

    Lima to Sacred Valley

    Lima to Sacred Valley
    Meals
    Lunch (Farm-to-table lunch at working corn farm)
    Accommodation
    Hotel (Explora Sacred Valley)

    Included Activities

    • Flight to Cusco
    • Visit to working corn farm at Hacienda Sarapampa
    • Farm-to-table lunch at Hacienda Sarapampa
    Landmarks
    Cusco
    Sacred Valley
    Itinerary Image 1
  16. Day 15

    Sacred Valley

    Sacred Valley
    Meals
    Lunch (Traditional lunch with Andes mountains and surrounding valleys views), Dinner (Dinner at hotel)
    Accommodation
    Hotel (Explora Sacred Valley)

    Included Activities

    • Welcome by local Misminay community
    • Traditional weaving demonstration
    • Traditional lunch with Andes views
    • Visit to Salt Mines of Maras
    • Visit to Moray archaeological site with Incan circular terraces
    • Guided exploration of Sacred Valley
    Landmarks
    Misminay Community
    Salt Mines of Maras
    Moray
    Andes Mountains
    Itinerary Image 1
  17. Day 16

    Sacred Valley to Aguas Calientes

    Sacred Valley to Aguas Calientes
    Meals
    Lunch (Gourmet Andean-inspired lunch on Inca Rail First Class train), Dinner (Dinner at hotel)
    Accommodation
    Hotel (Sumaq Machu Picchu Hotel)

    Included Activities

    • Inca Rail First Class Machu Picchu Train
    • Gourmet Andean-inspired lunch on board train
    Landmarks
    Aguas Calientes
    Itinerary Image 1
  18. Day 17

    Aguas Calientes to Cusco

    Aguas Calientes to Cusco
    Accommodation
    Hotel (Cusco)

    Included Activities

    • Locally guided exploration of Machu Picchu
    • PeruRail Vistadome Machu Picchu Train return journey
    Landmarks
    Machu Picchu
  19. Day 18

    Cusco

    Cusco
    Meals
    Dinner (Dinner at MAP Café in the central courtyard of the Museum of Pre-Columbian Art)
    Accommodation
    Hotel (Cusco)

    Included Activities

    • Guided discovery of Cusco
    • Visit to Plaza de Armas

    Optional Activities

    • Peruvian Cooking Class - Learn to prepare traditional Peruvian dishes and discover traditional ingredients
    • Sacsayhuamán Citadel Visit - Explore the 15th-century dry stone archaeological site
    Landmarks
    Plaza de Armas
    Sacsayhuamán
    Museum of Pre-Columbian Art
  20. Day 19

    Cusco to Amazon (Iquitos)

    Cusco to Amazon (Iquitos)
    Meals
    Lunch (Boxed lunch en route to Nauta), Dinner (Three-course dinner on board Delfin III)
    Accommodation
    Hotel (Amazon River)

    Included Activities

    • Coach transfer through rainforest with commentary
    • Skiff exploration along Marañón River at dusk
    • Three-course dinner on board Delfin III
    Landmarks
    Iquitos
    Peruvian Amazon
    Marañón River
    Itinerary Image 1
  21. Day 20

    Amazon River Cruise

    Amazon River Cruise
    Meals
    Lunch (Lunch on board Delfin III)
    Accommodation
    Hotel (Amazon River)

    Included Activities

    • Meeting with local Shaman to learn about rainforest plants and medicine
    • Kayaking along tributary tributaries
    Landmarks
    Peruvian Amazon
  22. Day 21

    Amazon River

    Amazon River
    Meals
    Breakfast, Lunch, Dinner
    Accommodation
    Hotel (Amazon River)

    Included Activities

    • Skiff fishing trip on Nauta Cañó
    • Wildlife viewing including piranha spotting
    • Local community visit and cultural exchange
    • Rainforest trail walk at Nauta Cañó
    • Guided viewing of Marañón and Ucayali rivers confluence
    Landmarks
    Nauta Cañó
    Marañón River
    Ucayali River
    Amazon River
  23. Day 22

    Amazon to Iquitos

    Amazon to Iquitos

    Included Activities

    • Visit to Tropical Amazon Aquarium
    Landmarks
    Tropical Amazon Aquarium

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What's Included

Expand All
  • Accommodation
  • Flights
  • Guide
  • Meals
  • Additional Services
  • Transport

What's Not Included

  • Insurance
  • Optional
  • Additional Services

Where You'll Stay

All accommodations are subject to change

Operated by

APT

Response time
within 1 day
Response rate
60%
Cancellation policy
Learn more

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Trip essentials

Good to know

Tour ID: 307089

The practical details for your trip across Chile, Argentina, Brazil and Peru: money, plugs and flexible ways to pay, all in one place.

Have a question? Chat with a travel expert

  • Deposit only

    Book now with just a $750 deposit. The remaining balance is due 120 days before departure.

  • 4 local currencies

    You’ll encounter Argentine Peso in Argentina, Brazilian Real in Brazil, Chilean Peso in Chile, Sol in Peru.

  • Plug types I, C, N, L, A

    You’ll need an adapter for these sockets in Chile, Argentina, Brazil and Peru.

  • Currencies

    $
    Argentine Peso

    Argentina

    R$
    Brazilian Real

    Brazil

    $
    Chilean Peso

    Chile

    S/.
    Sol

    Peru

  • Plugs & adapters

    As a traveler from USA, Canada you will need an adaptor for types I, C, N, L. As a traveler from England, South Africa you will need an adaptor for types I, C, N, L, A. As a traveler from Australia, New Zealand you will need an adaptor for types C, N, L, A.

    • Type I

      Only used in Argentina

    • Type C

      Only used in Brazil and Peru

    • Type N

      Only used in Brazil

    • Type L

      Only used in Chile

    • Type A

      Only used in Peru

  • Visa

    Whether you need a visa depends on your nationality and how long you stay. We can’t process visas for you, but here’s a quick indication for this trip.

    This is only an indication. Visa rules depend on your passport, trip length and purpose. Always confirm with the official embassy or consulate before you travel.

  • Payment information

    Pay now
    A $750 deposit
    Balance due
    120 days before departure
    Currency
    USD
    Booking fee
    None

    Book now with just a $750 deposit and pay the rest later. The remaining balance is due 120 days before departure, charged automatically to your card. Everything is charged in USD, and TourRadar never adds a booking fee. Any trip departing before February 3rd, 2027 will need to be paid in full at checkout.

    Accepted for APT tours

    • Visa
    • Maestro
    • Mastercard
    • American Express
    • PayPal

    TourRadar does NOT charge you an extra fee for using any of these payment methods.

  • Best price guarantee

    Found a lower price for the same tour elsewhere? We work directly with every tour operator, so we can match it.

    How it works

    1. Find a lower price

      Spot the same tour cheaper on another site or agency.

    2. Send us the quote

      Contact us before you book.

    3. We match it

      If the quote qualifies, you book with us at that price.

    Your quote needs

    • Same tour and operator
    • Same start and end dates
    • Same number of travelers
    • Same inclusions and destinations
    • Same booking and cancellation terms, in the same currency
    • A link to the site or agency offering it

    What doesn’t count

    • Quotes issued more than 24 hours ago
    • Cash back or loyalty program rebates
    • Itineraries that are similar but not identical
    • Similar tours run by a different operator
    • Bookings already confirmed on TourRadar

    Every new booking also counts toward your , which unlocks extra savings.

  • Cancellation Policy

    Cancellation terms may vary per tour. Please check for the full cancellation policy here.

    Checking the cancellation terms for this tour…

    Your money is protected. TourRadar is an authorized agent of APT, and we handle payments so you don’t have to. Payment is securely transferred to the operator based on your departure date.

  • Insurance

    Our travel protection from our award-winning partner, XCover, means you and your travel companions can book with peace of mind knowing there’s protection available in case your trip doesn’t go to plan. At checkout you will be able to select between different options in case you or the tour are eligible for insurance. In case no option is available, you are always able to purchase travel insurance outside of TourRadar.

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  • Accessibility

    Some tours are not suitable for mobility-restricted traveler, however, some operators may be able to accommodate special requests. For any enquiries, you can contact our customer support team, who are ready and waiting to help you.

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Who is travelling?

AdultsAges 18 or above

2

ChildrenUnder 18

0

Select departure month

2026

Jan
Feb
Mar
Apr
May
Jun
Jul
Aug
Sep
Oct
Nov
Dec

2027

Jan
Feb
Mar
Apr
May
Jun
Jul
Aug
Sep
Oct
Nov
Dec

2028

Jan
Feb
Mar
Apr
May
Jun
Jul
Aug
Sep
Oct
Nov
Dec