4-Week South America Tour Packages
Four weeks in South America is a big goal, but it's a real trip. You'll visit Iguazu Falls, explore Lima's colonial center, hike the ancient ruins of Machu Picchu, cruise the Amazon rainforest, learn about Buenos Aires' tango scene, and see Rio's Christ the Redeemer. Cross Peru, Brazil, and Argentina to see the glaciers in Patagonia and learn about cultures that range from Incan to European.
Insider tips: Recommended 4-week South America tour itineraries
Compiled by

NinaSouth America travel expert at TourRadar
25 Day South America Itinerary, incl. La Paz and Rio de Janeiro
Rich landscapes unfold over 25 days across 11 destinations from La Paz to Rio. The route encompasses Bolivia's salt flats, Chile's Atacama Desert, Argentina's colonial cities, and Brazil's tropical islands. Guided tours of Iguazu Falls from both countries and traditional estancia stays included.

- Days 1-2
La Paz, Bolivia
Welcome to the world's highest capital city at 3,500m. The fascinating Witches' Market (Mercado de Hechiceria) is a must-see, where local shamans sell traditional remedies and ceremonial items. Pack lots of warm layers since La Paz gets quite cold at night. Take an overnight bus to Uyuni - you'll get blankets and reclining seats for the journey.

- Days 3-5
Salar de Uyuni & Atacama Desert
The otherworldly Salar de Uyuni salt flats start with a visit to the Train Cemetery. Next up is Chile's Atacama Desert, where you'll find the red waters of Laguna Colorada full of flamingos. Expect basic facilities and very cold desert nights. One traveler shared: "The salt flats at sunrise were incredible, but bring warm socks and layers - I wasn't prepared for how cold it would be at dawn."

- Days 6-8
San Pedro de Atacama & Salta
Take time to explore San Pedro's old town square and try an astronomy tour under the clear desert sky. The drive to Salta, Argentina is long but beautiful. They call it "La Linda" (the beautiful) for good reason. You can climb 1,070 steps up Cerro San Bernardo or take the cable car for amazing valley views.

- Days 9-13
Buenos Aires & Uruguay
A quick flight takes you to energetic Buenos Aires. Walk through colorful La Boca and the historic San Telmo market. Take a boat to Uruguay's Colonia del Sacramento, a UNESCO site. Visit Montevideo before staying at a traditional estancia (ranch) for a real gaucho experience. A past guest wrote: "The estancia stay was a highlight - learning to ride horses and sharing meals with the local family gave us real insight into Uruguayan culture."

- Days 14-17
Iguazu Falls
- Days 18-20
Paraty & Ilha Grande
- Days 21-25
Rio de Janeiro
Ultimate Brazil, Patagonia & the Chilean Fjords
This 28-day route through Brazil, Uruguay, Argentina, and Chile takes you to Rio's Sugarloaf Mountain, colonial São Francisco do Sul, and Punta del Este's 'La Mano' sculpture. You'll see World Heritage Punta Piramides, cruise the 64-kilometer Cockburn Channel past glaciers, and reach Cape Horn where the Atlantic meets Pacific.

Rio de Janeiro Brazil
85 miBuzios Brazil
148 miVila do Abraao Brazil
3 miIlha Grande Brazil
31 miParaty Brazil
58 miIlhabela Brazil
264 miSão Francisco do Sul Brazil
707 miShow 6 more
Punta Del Este Uruguay
70 miMontevideo Uruguay
126 miBuenos Aires Argentina
126 miMontevideo Uruguay
686 miPuerto Piramides Argentina
792 miPunta Arenas Chile
21 miMagdalena Island Chile
126 miAlberto de Agostini National Park Chile
72 miBeagle Channel Chile
16 miUshuaia Argentina
1,474 miBuenos Aires Argentina
Treasures of South America: Chilean Fjords to the Iguazu falls - Cruise & Land Journey
This 27-day voyage through Argentina, Chile, Uruguay, and Brazil passes Cape Horn where two oceans meet. You'll see Punta Arenas as gateway to Torres del Paine, visit Magellanic penguin colonies at Isla Pingüino near Puerto Deseado, and spot southern right whales at UNESCO-listed Punta Piramides.

Buenos Aires Argentina
1,474 miUshuaia Argentina
91 miHornos Island Chile
91 miBeagle Channel Chile
72 miAlberto de Agostini National Park Chile
126 miMagdalena Island Chile
126 miAlberto de Agostini National Park Chile
111 miShow 2 more
Punta Arenas Chile
792 miPuerto Piramides Argentina
16 miValdes Peninsula Argentina
673 miMontevideo Uruguay
126 miBuenos Aires Argentina
665 miIguazu Falls Argentina
740 miRio de Janeiro Brazil
What people love about 4-week South America tours
- Ultimate South America (With Train To Machu Picchu)
One of the greatest trips I’ve ever been on! Clari is the best trip manager and the itinerary was phenomenal.
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