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From
US $22,698 per person

Best of South America with Amazon Cruise 2026 - Santiago to Iquitos, 2027/28 - Rio de Janeiro to Iquitos (2028)

22 days
•
From Rio de Janeiro to Iquitos
4.1
26 traveler reviews
  • Evening cityscape with baroque church façade illuminated as traffic light trails streak past.
  • Massive cyclopean stone walls of Saqsaywaman with a lone hiker under a deep blue Andean sky.
  • Colonial building and palm trees beneath a rainbow in a tropical town after rain.
  • Panoramic view over Copacabana Beach, Rio skyline and lush mountains beneath bright blue sky and Brazilian flag.
  • Small moto-taxis drive past a cathedral and landscaped plaza under patchy clouds.
    View all
  • Sun-soaked Ipanema Beach with sunbathers, umbrellas, palm tree promenade and iconic Two Brothers peaks.
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US $
+ $3,177 additional upfront costs

Price based on Cheapest Room

Price based on Shared Room

Price based on Private Single Room

Price based on Private Double Room

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2026

Jan
Feb
Mar
Apr
May
Jun
Jul
Aug
Sep
Oct
Nov
Dec

2027

Jan
Feb
Mar
Apr
May
Jun
Jul
Aug
Sep
Oct
Nov
Dec

2028

Jan
Feb
Mar
Apr
May
Jun
Jul
Aug
Sep
Oct
Nov
Dec
1 Adult2 Adults, 1 Child2 Children

Who is travelling?

AdultsAges 18 or above

2

ChildrenUnder 18

0
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Plan your adventure:
Operator
APT
Explorer
Curated to ignite your sense of adventure
Group Tour
Join a group and forge lifelong friendships
Fully Guided
An experienced guide will be with you for the entire tour
Low Intensity
Travelers can expect some light physical activities
Guided in English
Group Size 1 - 200
Ages 8+
Image of a map showing the route of the tour

Itinerary

  1. Day 1

    Rio de Janeiro

    Meals
    Dinner (Welcome dinner at hotel)
    Accommodation
    Hotel (Copacabana Palace)

    Included Activities

    • Welcome dinner at hotel
    Landmarks
    Copacabana Beach
    Itinerary Image 1Itinerary Image 2Itinerary Image 3
  2. Day 2

    Rio de Janeiro

    Meals
    Lunch (Brazilian barbecue at a local restaurant)
    Accommodation
    Hotel (Copacabana Palace)

    Included Activities

    • Visit to Corcovado and Christ the Redeemer
    • Cable car to Sugarloaf Mountain summit
    • Sunset drink at Sugarloaf Mountain
    Landmarks
    Christ the Redeemer
    Corcovado
    Sugarloaf Mountain
  3. Day 3

    Rio de Janeiro

    Accommodation
    Hotel (Copacabana Palace)

    Included Activities

    • Freedom of Choice - Tijuca National Park Jeep Tour
    • Freedom of Choice - Guanabara Bay Boat Tour
    Landmarks
    Tijuca National Park
    Guanabara Bay
  4. Day 4

    Rio de Janeiro to Iguazú Falls

    Accommodation
    Hotel (Iguazú Falls)

    Included Activities

    • Arrival on Brazilian side of Iguazú Falls with leisurely walks between viewing platforms
    • Freedom of Choice - Jet Boat Safari
    • Freedom of Choice - Helicopter Ride
    • Signature Experience at Gran Melía Iguazú
    Landmarks
    Iguazú Falls
  5. Day 5

    Iguazú Falls

    Accommodation
    Hotel (Iguazú Falls)

    Included Activities

    • Rainforest Ecological Train exploration
    • Walkways and viewpoints including Devil's Throat
    • Signature Experience - Wine Tasting with cheese pairings
    Landmarks
    Iguazú Falls
    Devil's Throat
  6. Day 6

    Iguazú Falls to Buenos Aires

    Accommodation
    Hotel (Buenos Aires)

    Included Activities

    • Signature Experience - Tango Demonstration and Tapas
    Landmarks
    Recoleta
  7. Day 7

    Buenos Aires

    Accommodation
    Hotel (Buenos Aires)

    Included Activities

    • Guided discovery of Buenos Aires including La Boca, Palermo, and La Recoleta Cemetery

    Optional Activities

    • Freedom of Choice Dining - Fogón Asado (Argentine barbecue)
    • Freedom of Choice Dining - Fervor (old-world steakhouse with grilled meats and seafood)
    • Freedom of Choice Dining - Dinner and Tango Show (tango show with Argentine dishes)
    Landmarks
    La Boca
    Palermo
    La Recoleta Cemetery
  8. Day 8

    Buenos Aires

    Accommodation
    Hotel (Buenos Aires)

    Included Activities

    • Freedom of Choice - Tigre Cruise
    • Freedom of Choice - Parisian Walking Tour
    • Freedom of Choice - Teatro Colón Tour
    Landmarks
    Tigre
    Paraná Delta
    Plaza San Martín
    Teatro Colón
  9. Day 9

    Buenos Aires to Santiago

    Meals
    Dinner
    Accommodation
    Hotel (The Ritz-Carlton)

    Included Activities

    • Dinner
    Landmarks
    Andes Mountains
  10. Day 10

    Santiago

    Accommodation
    Hotel (The Ritz-Carlton)

    Included Activities

    • Guided discovery of Santiago

    Optional Activities

    • Freedom of Choice Dining - Liguria Lastarria (Chilean dishes including empanadas, tuna tartare, pichanga, cocktails, wine, beer)
    • Freedom of Choice Dining - Ambrosia (Chilean and French fusion cuisine including ceviche)
  11. Day 11

    Santiago to Valparaíso

    Meals
    Lunch (Lunch at local vineyard)
    Accommodation
    Hotel (The Ritz-Carlton)

    Included Activities

    • Signature Experience - Valparaíso Funicular Ride
    • Lunch at local vineyard
    Landmarks
    Valparaíso
  12. Day 12

    Santiago to Lima

    Meals
    Dinner
    Accommodation
    Hotel (InterContinental Real Lima Miraflores)

    Included Activities

    • Dinner
  13. Day 13

    Lima

    Meals
    Lunch (Traditional lunch at private hacienda)
    Accommodation
    Hotel (InterContinental Real Lima Miraflores)

    Included Activities

    • Guided discovery of Lima's historic centre
    • Signature Experience - Peruvian Paso Horse Show (private hacienda, traditional lunch, horse show)
    • Visit to Pachacamac ruins
    Landmarks
    Pachacamac
  14. Day 14

    Lima to Sacred Valley

    Meals
    Breakfast, Lunch (Farm-to-table lunch at Hacienda Sarapampa)
    Accommodation
    Hotel (Tambo del Inka)

    Included Activities

    • Signature Experience - Hacienda Sarapampa Lunch (working corn farm, farm-to-table lunch)
    Landmarks
    Cusco
    Sacred Valley
  15. Day 15

    Sacred Valley - Maras - Moray

    Meals
    Lunch (Traditional lunch with Andes mountain views), Dinner
    Accommodation
    Hotel (Tambo del Inka)

    Included Activities

    • Signature Experience - Traditional Weaving Demonstration (Misminay community, weaving demonstration, traditional lunch with Andes views)
    • Signature Experience - Salt Mines of Maras and Moray Terraces
    • Guided exploration of Sacred Valley
    Landmarks
    Salt Mines of Maras
    Moray
  16. Day 16

    Sacred Valley to Machu Picchu

    Meals
    Lunch (Gourmet Andean-inspired lunch on board Inca Rail First Class train), Dinner
    Accommodation
    Hotel (Sumaq Machu Picchu Hotel)

    Included Activities

    • Signature Experience - Inca Rail First Class Machu Picchu Train (gourmet Andean-inspired lunch on board)
    • Guided exploration of Machu Picchu
    Landmarks
    Machu Picchu
    Aguas Calientes
  17. Day 17

    Machu Picchu to Cusco

    Meals
    Lunch (Lunch at local restaurant)
    Accommodation
    Hotel (JW Marriott El Convento Cusco or similar)

    Included Activities

    • Free time in Aguas Calientes
    • PeruRail Vistadome train return journey
    Landmarks
    Aguas Calientes
    Cusco
  18. Day 18

    Cusco

    Meals
    Dinner (Farewell dinner at MAP Café, Museum of Pre-Columbian Art)
    Accommodation
    Hotel (JW Marriott El Convento Cusco or similar)

    Included Activities

    • Guided discovery of Cusco including Plaza de Armas
    • Freedom of Choice - Peruvian Cooking Class
    • Freedom of Choice - Sacsayhuamán Citadel Visit
    Landmarks
    Plaza de Armas
    Sacsayhuamán
    Museum of Pre-Columbian Art
    Itinerary Image 1
  19. Day 19

    Cusco to Iquitos - Amazon Cruise

    Meals
    Lunch (Boxed lunch during coach travel), Dinner (Three-course dinner prepared by ship's chefs)
    Accommodation
    Hotel (Amazon River Basin)

    Included Activities

    • Coach travel from Iquitos to Nauta with commentary
    • Tender boat transfer to Delfin III
    • Meeting with naturalist guides
    • Skiff exploration along Marañón River
    Landmarks
    Iquitos
    Marañón River
  20. Day 20

    Amazon Cruise

    Meals
    Lunch
    Accommodation
    Hotel (Amazon River Basin)

    Included Activities

    • Meeting with local shaman and traditional medicine learning
    • Kayak exploration along tributary
    Landmarks
    Amazon River
  21. Day 21

    Amazon Cruise

    Accommodation
    Hotel (Amazon River Basin)

    Included Activities

    • Skiff excursion along Nauta Caño with fishing and wildlife spotting
    • Visit to local community
    • Rainforest trail walk at Nauta Caño
    • Viewing of Marañón and Ucayali rivers confluence
    Landmarks
    Nauta Caño
    Marañón River
    Ucayali River
  22. Day 22

    Depart Iquitos

    Included Activities

    • Visit to Tropical Amazon Aquarium
    Landmarks
    Tropical Amazon Aquarium

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What's Included

Expand All
  • Accommodation
  • Guide
  • Meals
  • Additional Services
  • Transport

What's Not Included

  • Flights
  • Insurance
  • Additional Services

Where You'll Stay

All accommodations are subject to change

  • Copacabana Palace

    Hotel
    Days 1, 2, 3

  • Iguazú Falls

    Hotel
    Days 4, 5

  • Buenos Aires

    Hotel
    Days 6, 7, 8

  • The Ritz-Carlton

    Hotel
    Days 9, 10, 11

  • InterContinental Real Lima Miraflores

    Hotel
    Days 12, 13

  • Tambo del Inka

    Hotel
    Days 14, 15

  • Sumaq Machu Picchu Hotel

    Hotel
    day 16

  • JW Marriott El Convento Cusco or similar

    Hotel
    Days 17, 18

  • Amazon River Basin

    Hotel
    Days 19, 20, 21

Operated by

APT

Response time
within 1 day
Response rate
63%
Cancellation policy

Reviews About This Operator

Dates & Availability

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2026

Jan
Feb
Mar
Apr
May
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Jul
Aug
Sep
Oct
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2027

Jan
Feb
Mar
Apr
May
Jun
Jul
Aug
Sep
Oct
Nov
Dec

2028

Jan
Feb
Mar
Apr
May
Jun
Jul
Aug
Sep
Oct
Nov
Dec
1 Adult2 Adults, 1 Child2 Children

Who is travelling?

AdultsAges 18 or above

2

ChildrenUnder 18

0
Upcoming departures
  • From Tuesday
    8 Feb, 2028
    To Tuesday
    29 Feb, 2028
    Not available in your region
  • From Tuesday
    7 Mar, 2028
    To Tuesday
    28 Mar, 2028
    Not available in your region
  • From Tuesday
    2 May, 2028
    To Tuesday
    23 May, 2028
    Not available in your region
  • From Tuesday
    13 Jun, 2028
    To Tuesday
    4 Jul, 2028
    Not available in your region
  • From Tuesday
    25 Jul, 2028
    To Tuesday
    15 Aug, 2028
    Not available in your region
  • From Tuesday
    22 Aug, 2028
    To Tuesday
    12 Sep, 2028
    Not available in your region
  • From Tuesday
    5 Sep, 2028
    To Tuesday
    26 Sep, 2028
    Not available in your region
  • 6 Other Unavailable Departures

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From
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+ $3,177 additional upfront costs

Price based on Cheapest Room

Price based on Shared Room

Price based on Private Single Room

Price based on Private Double Room

Select Date

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2026

Jan
Feb
Mar
Apr
May
Jun
Jul
Aug
Sep
Oct
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Dec

2027

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Jul
Aug
Sep
Oct
Nov
Dec

2028

Jan
Feb
Mar
Apr
May
Jun
Jul
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1 Adult2 Adults, 1 Child2 Children

Who is travelling?

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ChildrenUnder 18

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Good to Know

Tour ID: 351246

  • Currencies
    $
    Argentine Peso
    Argentina
    R$
    Brazilian Real
    Brazil
    $
    Chilean Peso
    Chile
    S/.
    Sol
    Peru
  • Plugs & Adapters

    As a traveler from USA, Canada, England, South Africa you will need an adaptor for types I, L. As a traveler from Australia, New Zealand you will need an adaptor for type L.

    Type I
    Argentina
    Type L
    Chile
  • Vaccines
    • These are only indications, so please visit your doctor before you travel to be 100% sure.
    • Typhoid - Recommended for Argentina.Brazil.Chile.Peru. Ideally 2 weeks before travel.
    • Hepatitis A - Recommended for Argentina.Brazil.Chile.Peru. Ideally 2 weeks before travel.
    • Hepatitis B - Recommended for Argentina.Brazil.Chile.Peru. Ideally 2 months before travel.
    • Rabies - Recommended for Argentina.Chile.Peru. Ideally 1 month before travel.
    • Yellow fever - Recommended for Argentina.Brazil.Peru. Ideally 10 days before travel.
    • Tuberculosis - Recommended for Brazil.Peru. Ideally 3 months before travel.
  • Visa
    • Unfortunately we cannot offer you a visa application service. Whether you need a visa or not depends on your nationality and where you wish to travel. Assuming your home country does not have a visa agreement with the country you're planning to visit, you will need to apply for a visa in advance of your scheduled departure.
    • Here is an indication for which countries you might need a visa. Please contact the local embassy for help applying for visas to these places.
  • Payment information
    • For any tour departing before September 21st, 2026 a full payment is necessary. For tours departing after September 21st, 2026, a minimum payment of $750 is required to confirm your booking with APT. The final payment will be automatically charged to your credit card on the designated due date. The final payment of the remaining balance is required at least 120 days prior to the departure date of your tour. TourRadar never charges you a booking fee and will charge you in the stated currency.
    • The following cards are accepted for "APT" tours: Visa, Maestro, Mastercard, American Express or PayPal. TourRadar does NOT charge you an extra fee for using any of these payment methods.
  • Cancellation Policy
  • Accessibility
    Some tours are not suitable for mobility-restricted traveler, however, some operators may be able to accommodate special requests. For any enquiries, you can contact our customer support team, who are ready and waiting to help you.
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Who is travelling?

AdultsAges 18 or above

2

ChildrenUnder 18

0

Select departure month

2026

Jan
Feb
Mar
Apr
May
Jun
Jul
Aug
Sep
Oct
Nov
Dec

2027

Jan
Feb
Mar
Apr
May
Jun
Jul
Aug
Sep
Oct
Nov
Dec

2028

Jan
Feb
Mar
Apr
May
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