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From
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Best of South America with Amazon Cruise 2026 - Santiago to Iquitos, 2027/28 - Rio de Janeiro to Iquitos (2028) (26 destinations)

22 days
•
From Rio de Janeiro to Iquitos
4.2 (27 reviews)
  • Aerial panorama of Lima’s Miraflores cliffs, parks and Pacific coastline stretching into the haze.
  • Colonial-era Cathedral of Lima dominates Plaza de Armas lined with palm trees and historic buildings.
  • Visitors stand on a viewing bridge surrounded by the thundering cascades of Iguazu Falls.
  • High-rise beachfront skyline of Rio de Janeiro with lush mountains and lagoon in the background.
  • Verdant island and towering curtains of Iguazu Falls framed by rainforest and tall palm trees.
    View all
  • Iconic Sugarloaf Mountain rises above Guanabara Bay and Rio’s skyline dotted with sailboats.
  • Powerful wall of water plunges into mist with a small adventure boat dwarfed below at Iguazu.
    View all
From
US $
+ $3,150 additional upfront costs

Price based on Cheapest Room

Price based on Shared Room

Price based on Private Single Room

Price based on Private Double Room

Select Date

Select departure month

2026

Jan
Feb
Mar
Apr
May
Jun
Jul
Aug
Sep
Oct
Nov
Dec

2027

Jan
Feb
Mar
Apr
May
Jun
Jul
Aug
Sep
Oct
Nov
Dec

2028

Jan
Feb
Mar
Apr
May
Jun
Jul
Aug
Sep
Oct
Nov
Dec
1 Adult2 Adults, 1 Child2 Children

Who is travelling?

AdultsAges 18 or above

2

ChildrenUnder 18

0

Best price guarantee Learn More

Plan your adventure:
Operator
APT
City & Culture
Immerse yourself in rich history and local traditions
Group Tour
Join a group and forge lifelong friendships
Fully Guided
An experienced guide will be with you for the entire tour
Low Intensity
Travelers can expect some light physical activities
Guided in English
Group Size 1 - 200
Ages 8+
Image of a map showing the route of the tour

Itinerary

  1. Day 1

    Rio de Janeiro

    Rio de Janeiro
    Meals
    Dinner (Welcome dinner at hotel)
    Accommodation
    Hotel (Copacabana Palace)

    Included Activities

    • Welcome dinner at hotel
    Landmarks
    Copacabana Beach
    Itinerary Image 1Itinerary Image 2
  2. Day 2

    Rio de Janeiro

    Rio de Janeiro
    Accommodation
    Hotel (Copacabana Palace)

    Included Activities

    • Visit to Corcovado and Christ the Redeemer
    • Cable car ride to Sugarloaf Mountain summit
    • Sunset drink at Sugarloaf Mountain

    Optional Activities

    • Lunch at local restaurant featuring Brazilian barbecue
    Landmarks
    Christ the Redeemer
    Corcovado
    Sugarloaf Mountain
  3. Day 3

    Rio de Janeiro

    Rio de Janeiro
    Accommodation
    Hotel (Copacabana Palace)

    Included Activities

    • Freedom of Choice sightseeing activity

    Optional Activities

    • Jeep tour through Tijuca National Park on open-top jeep
    • Guanabara Bay boat tour (half-day)
    Landmarks
    Tijuca National Park
    Guanabara Bay
  4. Day 4

    Rio de Janeiro to Iguazú Falls

    Rio de Janeiro to Iguazú Falls
    Accommodation
    Hotel (Iguazú Falls)

    Included Activities

    • Flight to Iguazú Falls
    • Panoramic walk between viewing platforms at Iguazú Falls
    • Signature Experience at Gran Melia Iguazú

    Optional Activities

    • Jet boat safari at Iguazú Falls
    • Helicopter ride over Iguazú Falls
    Landmarks
    Iguazú Falls
    Itinerary Image 1Itinerary Image 2Itinerary Image 3
  5. Day 5

    Iguazú Falls

    Iguazú Falls
    Meals
    Dinner (Wine tasting with cheese pairings)
    Accommodation
    Hotel (Iguazú Falls)

    Included Activities

    • Rainforest Ecological Train to Argentinian side of Iguazú Falls
    • Walkways and viewpoints including Devil's Throat
    • Signature Experience: Wine tasting with cheese pairings
    Landmarks
    Iguazú Falls
    Devil's Throat
  6. Day 6

    Iguazú Falls to Buenos Aires

    Iguazú Falls to Buenos Aires
    Meals
    Dinner (Tango demonstration and authentic tapas)
    Accommodation
    Hotel (Buenos Aires)

    Included Activities

    • Flight to Buenos Aires
    • Signature Experience: Tango demonstration and tapas
    Landmarks
    Recoleta
  7. Day 7

    Buenos Aires

    Buenos Aires
    Accommodation
    Hotel (Buenos Aires)

    Included Activities

    • Guided discovery of Buenos Aires including La Boca, Palermo, and La Recoleta Cemetery

    Optional Activities

    • Dinner at Fogón Asado featuring Argentine barbecued meats
    • Dinner at Fervor steakhouse with grilled meats and seafood
    • Dinner and tango show with Argentine dishes
    Landmarks
    La Boca
    Palermo
    La Recoleta Cemetery
  8. Day 8

    Buenos Aires

    Buenos Aires
    Accommodation
    Hotel (Buenos Aires)

    Included Activities

    • Freedom of Choice activity

    Optional Activities

    • Tigre cruise along rivers and canals of Paraná Delta
    • Parisian walking tour of Buenos Aires including Plaza San Martín and Plazoleta Pellegrini
    • Teatro Colón tour of iconic opera house
    Landmarks
    Tigre
    Paraná Delta
    Plaza San Martín
    Teatro Colón
  9. Day 9

    Buenos Aires to Santiago

    Buenos Aires to Santiago
    Meals
    Dinner
    Accommodation
    Hotel (The Ritz-Carlton)

    Included Activities

    • Flight to Santiago
    • Dinner
  10. Day 10

    Santiago

    Santiago
    Accommodation
    Hotel (The Ritz-Carlton)

    Included Activities

    • Guided discovery of Santiago

    Optional Activities

    • Dinner at Liguria Lastarria featuring empanadas, Chilean-style tuna tartare, pichanga, cocktails, wine and beer
    • Dinner at Ambrosia blending Chilean and French cuisine including ceviche
  11. Day 11

    Santiago to Valparaíso

    Santiago to Valparaíso
    Meals
    Lunch (Lunch at local vineyard)
    Accommodation
    Hotel (The Ritz-Carlton)

    Included Activities

    • Exploration of Valparaíso historic quarter
    • Funicular ride with views of Valparaíso
    • Lunch at local vineyard
    Landmarks
    Valparaíso
  12. Day 12

    Santiago to Lima

    Santiago to Lima
    Meals
    Dinner
    Accommodation
    Hotel (InterContinental Real Lima Miraflores)

    Included Activities

    • Flight to Lima
    • Dinner
    Itinerary Image 1Itinerary Image 2
  13. Day 13

    Lima

    Lima
    Meals
    Lunch (Traditional fare at private hacienda)
    Accommodation
    Hotel (InterContinental Real Lima Miraflores)

    Included Activities

    • Guided discovery of Lima's historic centre
    • Signature Experience at private hacienda with traditional lunch and Peruvian Paso horse show
    • Visit to Pachacamac ruins
    Landmarks
    Pachacamac
  14. Day 14

    Lima to Sacred Valley

    Lima to Sacred Valley
    Meals
    Breakfast, Lunch (Farm-to-table lunch at working corn farm)
    Accommodation
    Hotel (Tambo del Inka)

    Included Activities

    • Flight to Cusco
    • Signature Experience: Hacienda Sarapampa farm-to-table lunch at working corn farm
  15. Day 15

    Sacred Valley - Maras - Moray

    Sacred Valley - Maras - Moray
    Meals
    Lunch (Traditional lunch with views of Andes mountains and surrounding valleys), Dinner
    Accommodation
    Hotel (Tambo del Inka)

    Included Activities

    • Signature Experience: Traditional weaving demonstration with Misminay community and traditional lunch
    • Signature Experience: Salt Mines of Maras and Moray Terraces
    • Guided exploration of Salt Mines of Maras
    • Visit to Moray archaeological site
    Landmarks
    Salt Mines of Maras
    Moray
  16. Day 16

    Sacred Valley to Machu Picchu

    Sacred Valley to Machu Picchu
    Meals
    Lunch (Gourmet Andean-inspired lunch on Inca Rail First Class train), Dinner
    Accommodation
    Hotel (Sumaq Machu Picchu Hotel)

    Included Activities

    • Signature Experience: Inca Rail First Class Machu Picchu Train with gourmet Andean-inspired lunch
    • Guided exploration of Machu Picchu with local guide
    • Dinner at hotel
    Landmarks
    Machu Picchu
  17. Day 17

    Machu Picchu to Cusco

    Machu Picchu to Cusco
    Meals
    Lunch (Lunch at local restaurant)
    Accommodation
    Hotel (JW Marriott El Convento Cusco or similar)

    Included Activities

    • Train journey on PeruRail Vistadome train back to Sacred Valley
    • Lunch at local restaurant
    • Transfer to Cusco
    Landmarks
    Aguas Calientes
  18. Day 18

    Cusco

    Cusco
    Meals
    Dinner (Farewell dinner at MAP Café in Museum of Pre-Columbian Art)
    Accommodation
    Hotel (JW Marriott El Convento Cusco or similar)

    Included Activities

    • Guided discovery of Cusco including Plaza de Armas
    • Freedom of Choice activity
    • Farewell dinner at MAP Café

    Optional Activities

    • Peruvian cooking class with traditional dishes and ingredients
    • Sacsayhuamán citadel visit with 15th-century Incan dry-stone walls
    Landmarks
    Plaza de Armas
    Sacsayhuamán
  19. Day 19

    Cusco to Iquitos - Amazon Cruise

    Cusco to Iquitos - Amazon Cruise
    Meals
    Lunch (Boxed lunch en route to Nauta), Dinner (Three-course dinner on board Delfin III)
    Accommodation
    Hotel (Amazon River Basin)

    Included Activities

    • Flight to Iquitos via Lima
    • Coach transfer through rainforest to Nauta
    • Tender boat transfer to Delfin III
    • Skiff exploration along Marañón River at dusk
    • Three-course dinner on board
    Landmarks
    Marañón River
  20. Day 20

    Amazon Cruise

    Amazon Cruise
    Meals
    Lunch
    Accommodation
    Hotel (Amazon River Basin)

    Included Activities

    • Meeting with local shaman and traditional medicine education
    • Kayak exploration along tributary
    • Wildlife observation - birdlife, monkeys, pink river dolphins
    Landmarks
    Marañón River
  21. Day 21

    Amazon Cruise

    Amazon Cruise
    Accommodation
    Hotel (Amazon River Basin)

    Included Activities

    • Skiff excursion along Nauta Caño with fishing and wildlife spotting
    • Visit to local community
    • Rainforest trail walk at Nauta Caño
    • Visit to confluence of Marañón and Ucayali rivers
    Landmarks
    Nauta Caño
    Marañón River
    Ucayali River
  22. Day 22

    Depart Iquitos

    Depart Iquitos

    Included Activities

    • Disembarkation from Delfin III
    • Visit to Tropical Amazon Aquarium with over 60 species of tropical fish
    Landmarks
    Tropical Amazon Aquarium

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What's Included

Expand All
  • Accommodation
  • Guide
  • Meals
  • Additional Services
  • Transport

What's Not Included

  • Flights
  • Insurance
  • Additional Services

Where You'll Stay

All accommodations are subject to change

  • Copacabana Palace

    Hotel
    Days 1, 2, 3

  • Iguazú Falls

    Hotel
    Days 4, 5

  • Buenos Aires

    Hotel
    Days 6, 7, 8

  • The Ritz-Carlton

    Hotel
    Days 9, 10, 11

  • InterContinental Real Lima Miraflores

    Hotel
    Days 12, 13

  • Tambo del Inka

    Hotel
    Days 14, 15

  • Sumaq Machu Picchu Hotel

    Hotel
    day 16

  • JW Marriott El Convento Cusco or similar

    Hotel
    Days 17, 18

  • Amazon River Basin

    Hotel
    Days 19, 20, 21

Operated by

APT

Response time
within 1 day
Response rate
50%
Cancellation policy

Reviews About This Operator

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Dates & Availability

Select departure month and travellers

Select Date

Select departure month

2026

Jan
Feb
Mar
Apr
May
Jun
Jul
Aug
Sep
Oct
Nov
Dec

2027

Jan
Feb
Mar
Apr
May
Jun
Jul
Aug
Sep
Oct
Nov
Dec

2028

Jan
Feb
Mar
Apr
May
Jun
Jul
Aug
Sep
Oct
Nov
Dec
1 Adult2 Adults, 1 Child2 Children

Who is travelling?

AdultsAges 18 or above

2

ChildrenUnder 18

0
Upcoming departures
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  • 6 Other Unavailable Departures

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From
US $
+ $3,150 additional upfront costs

Price based on Cheapest Room

Price based on Shared Room

Price based on Private Single Room

Price based on Private Double Room

Select Date

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2026

Jan
Feb
Mar
Apr
May
Jun
Jul
Aug
Sep
Oct
Nov
Dec

2027

Jan
Feb
Mar
Apr
May
Jun
Jul
Aug
Sep
Oct
Nov
Dec

2028

Jan
Feb
Mar
Apr
May
Jun
Jul
Aug
Sep
Oct
Nov
Dec
1 Adult2 Adults, 1 Child2 Children

Who is travelling?

AdultsAges 18 or above

2

ChildrenUnder 18

0

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Good to Know

Tour ID: 347312

  • Currencies
    $
    Argentine Peso
    Argentina
    R$
    Brazilian Real
    Brazil
    $
    Chilean Peso
    Chile
    S/.
    Sol
    Peru
  • Plugs & Adapters

    As a traveler from USA, Canada you will need an adaptor for types I, C, N, L. As a traveler from England, South Africa you will need an adaptor for types I, C, N, L, A. As a traveler from Australia, New Zealand you will need an adaptor for types C, N, L, A.

    Type I
    Argentina
    Type C
    Brazil and Peru
    Type N
    Brazil
    Type L
    Chile
    Type A
    Peru
  • Vaccines
    • These are only indications, so please visit your doctor before you travel to be 100% sure.
    • Typhoid - Recommended for Argentina.Brazil.Chile.Peru. Ideally 2 weeks before travel.
    • Hepatitis A - Recommended for Argentina.Brazil.Chile.Peru. Ideally 2 weeks before travel.
    • Hepatitis B - Recommended for Argentina.Brazil.Chile.Peru. Ideally 2 months before travel.
    • Rabies - Recommended for Argentina.Chile.Peru. Ideally 1 month before travel.
    • Yellow fever - Recommended for Argentina.Brazil.Peru. Ideally 10 days before travel.
    • Tuberculosis - Recommended for Brazil.Peru. Ideally 3 months before travel.
  • Visa
    • Unfortunately we cannot offer you a visa application service. Whether you need a visa or not depends on your nationality and where you wish to travel. Assuming your home country does not have a visa agreement with the country you're planning to visit, you will need to apply for a visa in advance of your scheduled departure.
    • Here is an indication for which countries you might need a visa. Please contact the local embassy for help applying for visas to these places.
  • Payment information
    • For any tour departing before December 14th, 2026 a full payment is necessary. For tours departing after December 14th, 2026, a minimum payment of $750 is required to confirm your booking with APT. The final payment will be automatically charged to your credit card on the designated due date. The final payment of the remaining balance is required at least 120 days prior to the departure date of your tour. TourRadar never charges you a booking fee and will charge you in the stated currency.
    • The following cards are accepted for "APT" tours: Visa, Maestro, Mastercard, American Express or PayPal. TourRadar does NOT charge you an extra fee for using any of these payment methods.
  • Cancellation Policy
  • Insurance

    Our travel protection from our award-winning partner, XCover, means you and your travel companions can book with peace of mind knowing there’s protection available in case your trip doesn’t go to plan. At checkout you will be able to select between different options in case you or the tour are eligible for insurance. In case no option is available, you are always able to purchase travel insurance outside of TourRadar.

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  • Accessibility
    Some tours are not suitable for mobility-restricted traveler, however, some operators may be able to accommodate special requests. For any enquiries, you can contact our customer support team, who are ready and waiting to help you.
  • People also viewed

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Who is travelling?

AdultsAges 18 or above

2

ChildrenUnder 18

0

Select departure month

2026

Jan
Feb
Mar
Apr
May
Jun
Jul
Aug
Sep
Oct
Nov
Dec

2027

Jan
Feb
Mar
Apr
May
Jun
Jul
Aug
Sep
Oct
Nov
Dec

2028

Jan
Feb
Mar
Apr
May
Jun
Jul
Aug
Sep
Oct
Nov
Dec