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Best of South America with Amazon & Galápagos Cruises 2026 - Santiago to Guayaquil, 2027/28 - Rio de Janeiro to Guayaquil (2026)

29 days
From Santiago to Guayaquil
4.1
26 traveler reviews

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Plan your adventure:
Explorer
Curated to ignite your sense of adventure
Fully Guided
An experienced guide will be with you for the entire tour
Low Intensity
Travelers can expect some light physical activities
Guided in English
Group Size 1 - 200
Ages 8+
Image of a map showing the route of the tour

Itinerary

  1. Day 1

    Santiago

    Meals
    Dinner (Welcome dinner)
    Accommodation
    Hotel (Santiago)
    Itinerary Image 1
  2. Day 2

    Santiago

    Accommodation
    Hotel (Santiago)

    Included Activities

    • Guided discovery of Santiago

    Optional Activities

    • Dinner at Liguria Lastarria - traditional Chilean cuisine including empanadas, tuna tartar, and Chilean-style pichanga with cocktails, wine and beer
    • Dinner at Ambrosia - Chilean and French fusion cuisine including ceviche
    Landmarks
    Andes Mountains
  3. Day 3

    Santiago to Valparaíso

    Meals
    Lunch (Lunch at local vineyard)
    Accommodation
    Hotel (Santiago)

    Included Activities

    • Guided discovery of Valparaíso historic quarter
    • Valparaíso funicular ride
    • Lunch at local vineyard
    Landmarks
    Valparaíso
  4. Day 4

    Santiago to Buenos Aires

    Accommodation
    Hotel (Buenos Aires)

    Included Activities

    • Tango demonstration and tapas experience
    Landmarks
    Recoleta
    Itinerary Image 1
  5. Day 5

    Buenos Aires

    Accommodation
    Hotel (Buenos Aires)

    Included Activities

    • Guided discovery of Buenos Aires
    • Visit to La Boca barrio
    • Exploration of Palermo district
    • Visit to La Recoleta Cemetery

    Optional Activities

    • Dinner at Fogon Asado - South American barbecued meats
    • Dinner at Fervor - old-world steakhouse with Argentine grilled meats and seafood
    • Dinner and Tango Show - passionate tango performance with Argentine dishes
    Landmarks
    La Boca
    Palermo
    La Recoleta Cemetery
  6. Day 6

    Buenos Aires

    Accommodation
    Hotel (Buenos Aires)

    Included Activities

    • Freedom of Choice activity selection

    Optional Activities

    • Tigre Cruise - river and canal cruise in the Paraná Delta
    • Parisian Walking Tour - discover Plaza San Martin, Plazoleta Pellegrini and Parisian-influenced neighborhoods
    • Teatro Colón Tour - guided tour of the iconic opera house
    Landmarks
    Teatro Colón
    Plaza San Martin
    Paraná Delta
  7. Day 7

    Buenos Aires to Iguazú Falls

    Accommodation
    Hotel (Iguazú Falls)

    Included Activities

    • Rainforest Ecological Train to viewing points and Devil's Throat
    • Stay at Gran Melia Iguazú within Iguazú National Park
    Landmarks
    Iguazú Falls
    Devil's Throat
    Iguazú National Park
    Itinerary Image 1
  8. Day 8

    Iguazú Falls

    Accommodation
    Hotel (Iguazú Falls)

    Included Activities

    • Walks between viewing platforms on the Brazilian side
    • Wine tasting with cheese pairings at Gran Melia Iguazú

    Optional Activities

    • Jet Boat Safari - get up close to the roaring cascades of Iguazú Falls
    • Helicopter Ride - scenic helicopter ride over Iguazú Falls
    Landmarks
    Iguazú Falls
  9. Day 9

    Iguazú Falls to Rio de Janeiro

    Meals
    Dinner
    Accommodation
    Hotel (Copacabana Palace)

    Included Activities

    • Dinner at hotel
    Landmarks
    Copacabana Beach
    Itinerary Image 1
  10. Day 10

    Rio de Janeiro

    Meals
    Lunch (Brazilian barbecue at a local restaurant)
    Accommodation
    Hotel (Copacabana Palace)

    Included Activities

    • Visit to Corcovado and Christ the Redeemer statue
    • Lunch at a local restaurant with Brazilian barbecue
    • Cable car to Sugarloaf Mountain with sunset views and drink
    Landmarks
    Corcovado
    Christ the Redeemer
    Sugarloaf Mountain
  11. Day 11

    Rio de Janeiro

    Accommodation
    Hotel (Copacabana Palace)

    Included Activities

    • Freedom of Choice activity selection

    Optional Activities

    • Jeep Tour - open-top jeep exploration of Tijuca National Park
    • Guanabara Bay Boat Tour - half-day boat tour of Rio de Janeiro's coastline
    Landmarks
    Tijuca National Park
    Guanabara Bay
  12. Day 12

    Rio de Janeiro to Lima

    Meals
    Lunch (Lunch at Café del Museo)
    Accommodation
    Hotel (InterContinental Real Lima Miraflores)

    Included Activities

    • Lunch at Café del Museo
    • Visit to the Larco Museum
    Landmarks
    Larco Museum
    Itinerary Image 1
  13. Day 13

    Lima

    Meals
    Lunch (Traditional South American lunch at private hacienda)
    Accommodation
    Hotel (InterContinental Real Lima Miraflores)

    Included Activities

    • Guided discovery of Lima's historic centre
    • Visit to private hacienda with traditional lunch and Peruvian Paso horse show
    • Visit to Pachacamac ruins
    Landmarks
    Lima historic centre
    Pachacamac
  14. Day 14

    Lima to Sacred Valley

    Meals
    Breakfast, Lunch (Farm-to-table lunch at Hacienda Sarapampa)
    Accommodation
    Hotel (Explora Sacred Valley)

    Included Activities

    • Flight to Cusco
    • Farm-to-table lunch at Hacienda Sarapampa working corn farm
    Landmarks
    Cusco
    Sacred Valley
    Itinerary Image 1
  15. Day 15

    Sacred Valley - Maras, Moray

    Meals
    Lunch (Traditional lunch with views of Andes mountains and surrounding valleys), Dinner
    Accommodation
    Hotel (Explora Sacred Valley)

    Included Activities

    • Traditional weaving demonstration with Misminay community
    • Traditional lunch with Andes mountain views
    • Guided exploration of Sacred Valley
    • Visit to Salt Mines of Maras
    • Visit to Moray archaeological site
    • Dinner at hotel
    Landmarks
    Salt Mines of Maras
    Moray
  16. Day 16

    Sacred Valley to Machu Picchu

    Meals
    Lunch (Gourmet Andean-inspired lunch on board Inca Rail First Class Train), Dinner
    Accommodation
    Hotel (Sumaq Machu Picchu Hotel)

    Included Activities

    • Inca Rail First Class Machu Picchu Train journey with gourmet Andean-inspired lunch
    • Dinner at hotel
    Landmarks
    Aguas Calientes
    Itinerary Image 1
  17. Day 17

    Machu Picchu to Cusco

    Accommodation
    Hotel (Cusco)

    Included Activities

    • Locally guided exploration of Machu Picchu
    • PeruRail Vistadome Train return journey to Sacred Valley
    Landmarks
    Machu Picchu
  18. Day 18

    Cusco

    Meals
    Dinner (Dinner at MAP Café in the central courtyard of the Museum of Pre-Columbian Art)
    Accommodation
    Hotel (Cusco)

    Included Activities

    • Guided discovery of Cusco to Plaza de Armas
    • Peruvian Cooking Class
    • Sacsayhuamán Citadel Visit
    • Dinner at MAP Café
    Landmarks
    Plaza de Armas
    Sacsayhuamán
    Museum of Pre-Columbian Art
  19. Day 19

    Cusco to Iquitos - Amazon Cruise

    Meals
    Lunch (Boxed lunch en route to Nauta), Dinner (Three-course dinner on board)
    Accommodation
    Hotel (Amazon River)

    Included Activities

    • Flight to Iquitos
    • Coach transfer from Iquitos to Nauta with area commentary and boxed lunch
    • Skiff exploration along Marañón River at dusk
    • Three-course dinner on board
    Landmarks
    Iquitos
    Marañón River
    Itinerary Image 1Itinerary Image 2Itinerary Image 3
  20. Day 20

    Amazon Cruise

    Meals
    Lunch
    Accommodation
    Hotel (Amazon River)

    Included Activities

    • Meet and learn from local Shaman about rainforest medicine
    • Kayak exploration along calm tributary
    • Wildlife viewing including birds and pink river dolphins
    Landmarks
    Amazon River
  21. Day 21

    Amazon Cruise

    Accommodation
    Hotel (Amazon River)

    Included Activities

    • Fishing skiff exploration in Nauta Caño
    • Piranha fishing and discovery
    • Visit to local community
    • Rainforest trail walk through ecosystem
    • Visit to Marañón and Ucayali river confluence
    Landmarks
    Nauta Caño
    Marañón River
    Ucayali River
  22. Day 22

    Iquitos - Amazon Cruise to Lima

    Accommodation
    Hotel (Wyndham Grand Costa Del Sol Lima Airport)

    Included Activities

    • Visit to Rescue and Rehabilitation Center for River Mammals (Amazon Forever)
    Landmarks
    Amazon Forever
  23. Day 23

    Lima to Guayaquil

    Accommodation
    Hotel (Hotel del Parque)

    Optional Activities

    • Visit to Guayaquil Heritage Cemetery
    • Visit to Barrio Las Peñas
    • Visit to Parque Seminario
    Landmarks
    Guayaquil
    Guayaquil Heritage Cemetery
    Barrio Las Peñas
    Parque Seminario
  24. Day 24

    Galápagos Islands

    Accommodation
    Hotel (Galápagos Islands)

    Included Activities

    • Transfer to MC Hermes
    • Excursion to highlands of Santa Cruz Island
    • Visit to tortoise ranch
    • Exploration of volcanic formations
    Landmarks
    Santa Cruz Island
    Itinerary Image 1Itinerary Image 2Itinerary Image 3
  25. Day 25

    Galápagos Islands

    Included Activities

    • Trail navigation at Rábida Island red sand beach
    • Visit to saltwater lagoons and palo santo trees
    • Wildlife viewing including pelicans and birdlife
    • Ascent to Bartolomé Island summit with panoramic views
    • Optional swimming and snorkelling around Pinnacle Rock
    Landmarks
    Rábida Island
    Bartolomé Island
    Pinnacle Rock
  26. Day 26

    Galápagos Islands

    Included Activities

    • Visit to South Plaza island
    • Walk through cactus forest
    • Wildlife viewing including red-billed tropicbirds and swallow-tailed gulls
    • Observation of Galápagos land iguanas and sea lions
    • Exploration of northern shore with giant prickly pear cacti
    Landmarks
    South Plaza Island
  27. Day 27

    Galápagos Islands

    Included Activities

    • Visit to Pitt Point on San Cristóbal Island
    • Wildlife viewing including boobies and frigatebirds
    • Snorkelling around the island
    • Visit to Witch Hill's coastline
    • Swimming opportunity
    • Visit to freshwater lagoon with flamingos
    Landmarks
    San Cristóbal Island
    Pitt Point
    Itinerary Image 1Itinerary Image 2Itinerary Image 3
  28. Day 28

    Galápagos Islands to Guayaquil

    Accommodation
    Hotel (Hotel del Parque)

    Included Activities

    • Visit to Isla Lobos
    • Foot and boat exploration
    • Panga ride with wildlife viewing
    • Snorkelling with sea lion pups
    Landmarks
    Isla Lobos
  29. Day 29

    Guayaquil

    Meals
    Breakfast
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What's Included

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  • Accommodation
  • Flights
  • Guide
  • Meals
  • Additional Services
  • Transport

What's Not Included

  • Insurance
  • Optional
  • Additional Services

Where You'll Stay

All accommodations are subject to change

Operated by

APT

Number of tours

231

Age Range

8 to 99 years old

Response time

within 3 days

Response rate

67%

A family-owned company since its conception in the 1920s. APT had its...

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Travel Insurance

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Plan your adventure:

Good to Know

Tour ID: 307090

  • Currencies
    $
    Argentine Peso
    Argentina
    R$
    Brazilian Real
    Brazil
    $
    Chilean Peso
    Chile
    $
    US Dollar
    Ecuador
    S/.
    Sol
    Peru
  • Plugs & Adapters

    As a traveler from USA, Canada, England, South Africa you will need an adaptor for types I, L. As a traveler from Australia, New Zealand you will need an adaptor for type L.

    Type I
    Argentina
    Type L
    Chile
  • Vaccines
    • These are only indications, so please visit your doctor before you travel to be 100% sure.
    • Typhoid - Recommended for Argentina.Brazil.Chile.Ecuador.Peru. Ideally 2 weeks before travel.
    • Hepatitis A - Recommended for Argentina.Brazil.Chile.Ecuador.Peru. Ideally 2 weeks before travel.
    • Hepatitis B - Recommended for Argentina.Brazil.Chile.Ecuador.Peru. Ideally 2 months before travel.
    • Rabies - Recommended for Argentina.Chile.Ecuador.Peru. Ideally 1 month before travel.
    • Yellow fever - Recommended for Argentina.Brazil.Ecuador.Peru. Ideally 10 days before travel.
    • Tuberculosis - Recommended for Brazil.Ecuador.Peru. Ideally 3 months before travel.
  • Visa
    • Unfortunately we cannot offer you a visa application service. Whether you need a visa or not depends on your nationality and where you wish to travel. Assuming your home country does not have a visa agreement with the country you're planning to visit, you will need to apply for a visa in advance of your scheduled departure.
    • Here is an indication for which countries you might need a visa. Please contact the local embassy for help applying for visas to these places.
  • Payment information
    • For any tour departing before August 15th, 2026 a full payment is necessary. For tours departing after August 15th, 2026, a minimum payment of $750 is required to confirm your booking with APT. The final payment will be automatically charged to your credit card on the designated due date. The final payment of the remaining balance is required at least 120 days prior to the departure date of your tour. TourRadar never charges you a booking fee and will charge you in the stated currency.
    • The following cards are accepted for "APT" tours: Visa, Maestro, Mastercard, American Express or PayPal. TourRadar does NOT charge you an extra fee for using any of these payment methods.
  • Cancellation Policy
  • Accessibility
    Some tours are not suitable for mobility-restricted traveler, however, some operators may be able to accommodate special requests. For any enquiries, you can contact our customer support team, who are ready and waiting to help you.

Who is travelling?

AdultsAges 18 or above

2

ChildrenUnder 18

0

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2026

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2027

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2028

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