What are the main destinations visited between Ho Chi Minh City and Siem Reap?

Your journey along the Mekong Delta takes you through vibrant local spots and historic sites. You'll explore the lively floating markets in Cai Be and visit Sa Dec, a charming colonial town known from the novel "The Lover" by Marguerite Duras. The route includes stops at the border town of Tan Chau, then continues to Phnom Penh where you can visit the Royal Palace and Silver Pagoda. You'll also get to know rural life in traditional villages like Angkor Ban and Kampong Cham. One TourRadar traveler shared: "The stops at local villages and markets provided authentic cultural experiences that felt untouched by tourism."

How do you travel between Ho Chi Minh City and Siem Reap?

Most of your journey takes place on comfortable river ships like the RV Indochine, RV Apsara, or Emerald Harmony as you cruise the Mekong River. When you visit local spots, you'll switch to smaller boats called sampans to explore floating markets, hop on tuk-tuks to get around Phnom Penh, and take buses for some land transfers. TourRadar travelers often mention that the cruise ships offer "comfort and colonial-style charm" while giving you an up-close look at life along the Mekong.

What unique cultural experiences are included in these tours?

You'll get to know local life through village visits, temple stops, and market tours. The journey includes exploring the Cu Chi Tunnels near Ho Chi Minh City, watching silk weavers at work in villages like Tan Chau, receiving special blessings from Buddhist monks in Oudong, and seeing traditional Apsara dancers perform in Phnom Penh. As one TourRadar traveler put it, these experiences offered "deep insights into the local way of life and traditions."

What kind of food will I eat during the trip?

You'll get to try lots of Vietnamese and Cambodian dishes, with most meals included on your cruise ship. The food experiences range from tasting tropical fruits at Mekong Delta orchards to enjoying fresh seafood in Chau Doc and trying local specialties at Phnom Penh's markets. The ships serve breakfast, lunch, and dinner with both local dishes and familiar Western options. One TourRadar traveler mentioned that the "refined local cuisine offers a perfect introduction to the region's flavors."

How long are the river cruise tours from Ho Chi Minh City to Siem Reap?

Most trips last 8-10 days, with about 7-9 nights spent cruising the Mekong River. Scenic Luxury Cruises runs a 10-day trip on their Scenic Spirit ship, while AmaWaterways offers an 8-day journey on the AmaDara. TourRadar travelers like the trip timing, with one saying "the cruise was excellent" with enough time to see important places like Phnom Penh, Sa Dec, and Angkor Ban while enjoying the river views.

How much do Ho Chi Minh City to Siem Reap river cruise tours cost?

Tour prices start at 2,184 USD and can go up to 12,990 USD per person, working out to about 243-1,299 USD per day. The price depends on how fancy you want to go. For example, Scenic Luxury Cruises' 10-day trip includes personal butler service and stays at nice hotels like the Caravelle Hotel Saigon. CroisiEurope follows similar routes but offers more moderate prices with different levels of accommodation.

River Cruises from Ho Chi Minh City to Siem Reap

Discover river cruises that depart from Ho Chi Minh City and end in Siem Reap. Cruises from Ho Chi Minh City to Siem Reap are most popular in November, with the most cruises doing this route then.

10 best River cruises from Ho Chi Minh City to Siem Reap

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River Cruise
From the Mekong Delta to the Angkor Temples (port-to-port cruise) (12 destinations)
4.8 (2 traveler reviews)
"Knowledgeable, fluent in English, friendly, and concerned about our safety always."
Awadesh, traveled in October
Duration
11 days
Destinations
Ho Chi Minh City, My Tho, Vinh Long, Cai Be, Sa Dec,Chau Doc,Phnom Penh,Koh Chen,Kampong Tralach,Kampong Chhnang,Tonle Sap Lake,Siem Reap+7 more
Age Range
All Ages Welcome
Ships
RV Indochine RV Indochine II RV Lan Diep+2 ships
River
Mekong
Operated in
English
Operator
CroisiEurope River Cruises
From
US$3,648per person
Price based on Private Double Room
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River Cruise
From the Mekong Delta to Siem Reap (port-to-port cruise) (11 destinations)
5.0 (1 traveler review)
Duration
9 days
Destinations
Ho Chi Minh City, My Tho, Vinh Long, Cai Be, Sa Dec,Chau Doc,Phnom Penh,Koh Chen,Kampong Tralach,Tonle Sap Lake,Siem Reap+6 more
Age Range
All Ages Welcome
Ships
RV Indochine RV Indochine II RV Lan Diep+2 ships
River
Mekong
Operated in
English
Operator
CroisiEurope River Cruises
From
US$2,326per person
Price based on Private Double Room
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River Cruise
Essential Vietnam and Cambodia Ho Chi Minh City to Siem Reap (2025)
Duration
12 days
Destinations
Ho Chi Minh City, My Tho, Cai Be, Sa Dec, Tan Chau,Phnom Penh,Oudong,Koh Chen,Kampong Cham,Siem Reap+5 more
Age Range
Ages 8+
River
Mekong
Operated in
English
Operator
APT
From
US$3,801per person
+$482 upfront costs
Price based on Private Double Room
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River Cruise
7-Night Vietnam to Cambodia - Mekong River Cruise & Dolphin Encounter
Duration
8 days
Destinations
Ho Chi Minh City, My Tho, Thới Bình, Cai Be, My An Hung,Phnom Penh,Kampong Cham,Kratie,Siem Reap+4 more
Age Range
Ages 12+
Operated in
English
Operator
Lotus Cruises
From
US$2,589per person
Price based on Private Double Room
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River Cruise
Treasures of the Mekong Meandering Cruise 2026|2027 - 15 Days
Duration
15 days
Destinations
Ho Chi Minh City, Cu Chi, My Tho, Cai Be, Tan Phong, Sa Dec,Tan Chau,Chau Doc,Phnom Penh,Oudong,Silk Island,Angkor Ban,Kampong Cham,Hanchey,Siem Reap+9 more
Age Range
Ages 18+
Ship
Scenic Spirit
Operated in
English
Operator
Scenic Luxury Cruises & Tours
56% Off
From $13,795
US$6,125per person
Price based on Private Double Room
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River Cruise
Wonders of Vietnam, Cambodia & the Mekong 2026-2027|2027-2028
Duration
13 days
Destinations
Ho Chi Minh City, Ben Tre, Sa Dec, My An Hung,Cu Lao Gieng,Tan Chau,Phnom Penh,Oudong,Siem Reap+5 more
Age Range
Ages 12+
River
Mekong
Operated in
English
Operator
Emerald Cruises
48% Off
From $10,915
US$5,670per person
Price based on Private Double Room
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River Cruise
Enchanting Mekong and Siem Reap 2026-2027|2027-2028 - 11 Days (from Ho Chi Minh City to Siem Reap)
Duration
11 days
Destinations
Ho Chi Minh City, Ben Tre, Sa Dec, My An Hung,Cu Lao Gieng,Tan Chau,Phnom Penh,Oudong,Siem Reap+5 more
Age Range
Ages 12+
River
Mekong
Operated in
English
Operator
Emerald Cruises
6% Off
From $4,510
US$4,222per person
Price based on Private Double Room
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River Cruise
Charms of the Mekong 2027
Duration
8 days
Destinations
Ho Chi Minh City, My Tho, Mekong Delta, Cai Be, Sa Dec,Tan Chau,Phnom Penh,Oudong,Kampong Tralach,Silk Island,Angkor Ban,Kampong Cham,Siem Reap+8 more
Age Range
Ages 12+
Ship
AmaDara
Operated in
English
Operator
AmaWaterways
6% Off
From
US$2,899per person
+$280 upfront costs
Price based on Private Double Room
- Booking needs min. 2 travelers
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River Cruise
The Mekong in a different way - Between adventure and must-see sites (port-to-port cruise) (from Ho Chi Minh City to Siem Reap)
Duration
9 days
Destinations
Ho Chi Minh City, Cai Be, Sa Dec, Chau Doc, Phnom Penh,Kampong Tralach,Koh Chen,Siem Reap+3 more
Age Range
All Ages Welcome
River
Mekong
Operated in
English
Operator
CroisiEurope River Cruises
6% Off
From
US$1,954per person
Price based on Private Double Room
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River Cruise
The Mekong in a different way - Between adventure and must-seesites (13 destinations)
Duration
9 days
Destinations
Ho Chi Minh City, My Tho, Thoi Son Island, Mekong Delta,Cai Be,Sa Dec,Chau Doc,Vinh Xuong,Phnom Penh,Koh Chen,Kampong Tralach,Tonle Sap Lake,Siem Reap+9 more
Age Range
All Ages Welcome
River
Mekong
Operated in
English
Operator
CroisiEurope River Cruises
6% Off
From
US$1,754per person
Price based on Private Double Room
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River Cruise
7-night Mekong Upstream Vietnam Cambodia on Mekong Navigator
5.0 (4 traveler reviews)
"Informed guides, an incredibly friendly & supportive staff, luxurious accomodations & a wonderful itinerary."
David, traveled in April
Duration
8 days
Destinations
Ho Chi Minh City, My Tho, Cai Be, Sa Dec, Cu Lao Gieng,Phnom Penh,Kampong Cham,Siem Reap+3 more
Age Range
Ages 12+
Ship
Mekong Navigator
River
Mekong
Operated in
English, German
Operator
Lotus Cruises
6% Off
From
US$3,233per person
Price based on Private Double Room
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River Cruise
The Mekong in a different way - Between adventure and must-seesites (port-to-port cruise) (from Ho Chi Minh City to Siem Reap)
4.8 (2 traveler reviews)
Duration
11 days
Destinations
Ho Chi Minh City, My Tho, Cai Be, Sa Dec, Chau Doc,Phnom Penh,Oudong,Kampong Tralach,Koh Chen,Siem Reap+5 more
Age Range
All Ages Welcome
River
Mekong
Operated in
English
Operator
CroisiEurope River Cruises
6% Off
From
US$2,682per person
Price based on Private Double Room
View tour
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River Cruise
The Mekong in a different way - Between adventure and must-seesites (10 destinations)
4.8 (2 traveler reviews)
Duration
11 days
Destinations
Ho Chi Minh City, My Tho, Cai Be, Sa Dec, Chau Doc,Phnom Penh,Oudong,Kampong Tralach,Koh Chen,Siem Reap+5 more
Age Range
All Ages Welcome
River
Mekong
Operated in
English
Operator
CroisiEurope River Cruises
6% Off
From
US$2,304per person
Price based on Private Double Room
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River Cruise
From the Mekong Delta to Siem Reap
5.0 (1 traveler review)
Duration
9 days
Destinations
Ho Chi Minh City, My Tho, Cai Be, Sa Dec, Chau Doc,Phnom Penh,Koh Chen,Kampong Tralach,Tonle Sap Lake,Siem Reap+5 more
Age Range
All Ages Welcome
Ships
RV Indochine RV Indochine II RV Lan Diep+2 ships
River
Mekong
Operated in
English
Operator
CroisiEurope River Cruises
6% Off
From
US$2,019per person
Price based on Private Double Room
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River Cruise
Spiritual Cambodia and the Mekong Ho Chi Minh City → Siem Reap (2026)
Duration
11 days
Destinations
Ho Chi Minh City, My Tho, Cai Be, Sa Dec, Tan Chau,Phnom Penh,Oudong,Koh Chen,Koh Oknha Tei,Angkor Ban,Hanchey,Kampong Cham,Koh Pen,Siem Reap+9 more
Age Range
Ages 8+
River
Mekong
Operated in
English
Operator
APT
6% Off
From
US$4,450per person
+$569 upfront costs
Price based on Private Double Room
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