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River Cruises from Ho Chi Minh City to Siem Reap
River Cruises from Ho Chi Minh City to Siem Reap

River Cruises from Ho Chi Minh City to Siem Reap

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  1. From the Mekong Delta to Siem Reap (port-to-port cruise) (11 destinations)Map of From the Mekong Delta to Siem Reap (port-to-port cruise) (11 destinations)
    River Cruise

    From Ho Chi Minh City's Ba Thien Hau Pagoda and Cu Chi tunnels, the route continues through My Tho and Chau Doc to Siem Reap. This 2,700-mile voyage aboard vessels like RV Indochine II offers colonial-style comfort and expert guides throughout.

    Duration 9 days
    DestinationsHo Chi Minh City, My Tho, Vinh Long, Cai Be, Sa Dec, Chau Doc, Phnom Penh, Koh Chen, Kampong Tralach, Tonle Sap LakeSee all destinations
    Age Range up to 99 year olds
    OperatorCroisiEurope River Cruises

    From

    US$2,320
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  2. 7-Night Christmas Cruise on the Mekong Navigator: Vietnam & CambodiaMap of 7-Night Christmas Cruise on the Mekong Navigator: Vietnam & Cambodia
    River Cruise
    Duration 8 days
    DestinationsHo Chi Minh City, My Tho, Ben Tre, Cu Lao Gieng, Tan Chau, Phnom Penh, Kampong Cham, Siem Reap
    Age Range 12 to 90 year olds
    OperatorLotus Cruises

    From

    US$3,699
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  3. Essential Vietnam and Cambodia Ho Chi Minh City to Siem Reap (2025)Map of Essential Vietnam and Cambodia Ho Chi Minh City to Siem Reap (2025)
    River Cruise

    A 12-day route from Ho Chi Minh City to Siem Reap aboard RV Apsara takes in Mekong Delta's floating markets and Phnom Penh's Royal Palace, concluding at UNESCO-listed Angkor Wat. Guests stay at Le Meridien Saigon and Shinta Mani Angkor.

    Duration 12 days
    DestinationsHo Chi Minh City, My Tho, Cai Be, Sa Dec, Tan Chau, Phnom Penh, Oudong, Koh Chen, Kampong Cham, Siem Reap
    Age Range up to 99 year olds
    OperatorAPT

    From

    US$3,103
    +$468 upfront costs
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  4. Fascinating Vietnam, Cambodia & the Mekong River (Northbound) 2025Map of Fascinating Vietnam, Cambodia & the Mekong River (Northbound) 2025
    River Cruise

    A 7-night sailing aboard Avalon Saigon takes you from Ho Chi Minh City through Vietnam's Mekong Delta to Cambodia. The route includes Vinh Long's traditional workshops and Phnom Penh's Silver Pagoda, finishing in Siem Reap near the ancient Angkor Wat temple complex.

    Duration 13 days
    DestinationsHo Chi Minh City, Vinh Long, Cu Lao Gieng, Chau Doc, Long Khanh, Phnom Penh, Hanchey, Angkor Ban, Kampong Tralach, Siem Reap
    Age Range 8 to 99 year olds
    OperatorAvalon Waterways

    From

    US$7,519
    +$150 upfront costs
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  5. Wonders of Vietnam, Cambodia & the Mekong 2025|2026Map of Wonders of Vietnam, Cambodia & the Mekong 2025|2026
    River Cruise

    Setting out from Ho Chi Minh City's District 1, this 9-night cruise aboard Emerald Harmony navigates the Mekong Delta. The route passes through Sa Dec's markets and My An Hung's pepper farms, culminating at Siem Reap's UNESCO-listed Angkor temples with stays at the boutique Shinta Mani.

    Duration 15 days
    DestinationsHo Chi Minh City, Cu Chi, Mekong Delta, Ben Tre, Sa Dec, My An Hung, Tan Chau, Phnom Penh, Koh Oknha Tei, Angkor BanSee all destinations
    Age Range up to 90 year olds
    OperatorEmerald Cruises

    From $10,950

    53% Off
    US$5,155
    You save $5,795
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  6. Charms of the Mekong 2027Map of Charms of the Mekong 2027
    River Cruise

    The voyage starts at Ho Chi Minh City's Sofitel Saigon Plaza, taking guests to Siem Reap across 8 days. The route winds through My Tho Port, Sa Dec's markets, and Cambodia's Silk Island aboard AmaDara, ending at Sofitel Angkor hotel with transfers included.

    Duration 8 days
    DestinationsHo Chi Minh City, My Tho, Mekong Delta, Cai Be, Sa Dec, Tan Chau, Phnom Penh, Oudong, Kampong Tralach, Silk IslandSee all destinations
    Age Range up to 90 year olds
    OperatorAmaWaterways

    From

    53% Off
    US$3,199
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  7. From the Mekong Delta to Siem ReapMap of From the Mekong Delta to Siem Reap
    River Cruise

    Your journey opens in Ho Chi Minh City with Cu Chi tunnels and Cholon market visits, followed by stops in My Tho and Chau Doc. This 9-day, 2,700-mile expedition aboard RV Indochine ships visits 10 cities across Vietnam and Cambodia, concluding at Siem Reap's Tonle Sap Lake.

    Duration 9 days
    DestinationsHo Chi Minh City, My Tho, Cai Be, Sa Dec, Chau Doc, Phnom Penh, Koh Chen, Kampong Tralach, Tonle Sap Lake, Siem Reap
    Age Range up to 99 year olds
    OperatorCroisiEurope River Cruises

    From

    53% Off
    US$2,079
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  8. From the Mekong Delta to Siem Reap (port-to-port cruise) (12 destinations)Map of From the Mekong Delta to Siem Reap (port-to-port cruise) (12 destinations)
    River Cruise
    Duration 9 days
    DestinationsHo Chi Minh City, My Tho, Vinh Long, Cai Be, Sa Dec, Chau Doc, Phnom Penh, Koh Chen, Kampong Tralach, Kompong ChhnangSee all destinations
    Age Range up to 99 year olds
    OperatorCroisiEurope River Cruises

    From

    53% Off
    US$2,320
    View tour
  9. The Mekong in a different way - Between adventure and must-seesites (port-to-port cruise) (from Ho Chi Minh City to Siem Reap)Map of The Mekong in a different way - Between adventure and must-seesites (port-to-port cruise) (from Ho Chi Minh City to Siem Reap)
    River Cruise

    The route starts at Ho Chi Minh City's Reunification Palace and War Museum, followed by an 11-day cruise to Siem Reap via Mekong Delta. Aboard Toum Tiou 2, you'll pass through Chao Gao canal, Tra Su Forest, and end at Angkor temples, visiting 10 cities across Vietnam and Cambodia.

    Duration 11 days
    DestinationsHo Chi Minh City, My Tho, Cai Be, Sa Dec, Chau Doc, Phnom Penh, Oudong, Kampong Tralach, Koh Chen, Siem Reap
    Age Range up to 99 year olds
    OperatorCroisiEurope River Cruises

    From

    53% Off
    US$2,676
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  10. The Mekong in a different way - Between adventure and must-seesites (10 destinations)Map of The Mekong in a different way - Between adventure and must-seesites (10 destinations)
    River Cruise

    Your adventure from Ho Chi Minh City includes Giac Lam Pagoda and Reunification Palace, continuing through Chao Gao canal to My Tho. The 11-day voyage aboard intimate Toum Tiou 2 covers 10 destinations before concluding in Siem Reap at the Angkor temples.

    Duration 11 days
    DestinationsHo Chi Minh City, My Tho, Cai Be, Sa Dec, Chau Doc, Phnom Penh, Oudong, Kampong Tralach, Koh Chen, Siem Reap
    Age Range up to 99 year olds
    OperatorCroisiEurope River Cruises

    From

    53% Off
    US$2,305
    View tour
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