Think about cruising from the Mekong Delta all the way to Angkor's temples. You'll explore the Reunification Palace, navigate Cu Chi tunnels, sample honey tea at bee farms, and float through twelve incredible destinations across Southeast Asia. This is culture on a different level, teaching you about a new way of life you might otherwise miss.
10 best River cruises from Ho Chi Minh City to Siem Reap
From the Mekong Delta to the Angkor Temples (port-to-port cruise) (from Ho Chi Minh City to Siem Reap)
4.8 (2 traveler reviews)"Knowledgeable, fluent in English, friendly, and concerned about our safety always."
- Duration
- 11 days
- Destinations
- Ho Chi Minh City, Cu Chi, My Tho, Vinh Long, Sa Dec,Chau Doc,Phnom Penh,Koh Chen,Kampong Tralach,Kampong Chhnang,Siem Reap,Tonle Sap Lake,Angkor Wat+8 more
- Age Range
- All Ages Welcome
- Ships
- RV IndochineRV Indochine II RV Lan Diep+2 ships
- River
- Mekong
- Operated in
- English
- Operator
- CroisiEurope River Cruises
14% Off- From $4,164
- US$3,585per person
Price based on Private Double Room
From the Mekong Delta to Siem Reap (port-to-port cruise) (11 destinations)
5.0 (1 traveler review)- Duration
- 9 days
- Destinations
- Ho Chi Minh City, My Tho, Vinh Long, Cai Be, Sa Dec,Chau Doc,Phnom Penh,Koh Chen,Kampong Tralach,Tonle Sap Lake,Siem Reap+6 more
- Age Range
- All Ages Welcome
- Ships
- RV IndochineRV Indochine II RV Lan Diep+2 ships
- River
- Mekong
- Operated in
- English
- Operator
- CroisiEurope River Cruises
14% Off- From
- US$2,315per person
Price based on Private Double Room
7-Night Vietnam to Cambodia - Mekong River Cruise & Dolphin Encounter
- Duration
- 8 days
- Destinations
- Ho Chi Minh City, My Tho, Thới Bình, Cai Be, My An Hung,Phnom Penh,Kampong Cham,Kratie,Siem Reap+4 more
- Age Range
- Ages 12+
- Operated in
- English
- Operator
- Lotus Cruises
14% Off- From
- US$2,589per person
Price based on Private Double Room
Treasures of the Mekong Meandering Cruise 2026|2027 - 15 Days
- Duration
- 15 days
- Destinations
- Ho Chi Minh City, Cu Chi, My Tho, Cai Be, Tan Phong, Sa Dec,Tan Chau,Chau Doc,Phnom Penh,Oudong,Silk Island,Angkor Ban,Kampong Cham,Hanchey,Siem Reap+9 more
- Age Range
- Ages 18+
- Ship
- Scenic Spirit
- Operated in
- English
- Operator
- Scenic Luxury Cruises & Tours
Deal- From
- US$14,525per person
Price based on Private Double Room
Wonders of Vietnam, Cambodia & the Mekong 2026-2027|2027-2028
- Duration
- 13 days
- Destinations
- Ho Chi Minh City, Ben Tre, Sa Dec, My An Hung,Cu Lao Gieng,Tan Chau,Phnom Penh,Oudong,Siem Reap+5 more
- Age Range
- Ages 12+
- River
- Mekong
- Operated in
- English
- Operator
- Emerald Cruises
Deal- From
- US$10,915per person
Price based on Private Double Room
Enchanting Mekong and Siem Reap 2026-2027|2027-2028 - 11 Days (from Ho Chi Minh City to Siem Reap)
- Duration
- 11 days
- Destinations
- Ho Chi Minh City, Ben Tre, Sa Dec, My An Hung,Cu Lao Gieng,Tan Chau,Phnom Penh,Oudong,Siem Reap+5 more
- Age Range
- Ages 12+
- River
- Mekong
- Operated in
- English
- Operator
- Emerald Cruises
6% Off- From $4,579
- US$4,287per person
Price based on Private Double Room
Charms of the Mekong 2027
- Duration
- 8 days
- Destinations
- Ho Chi Minh City, My Tho, Mekong Delta, Cai Be, Sa Dec,Tan Chau,Phnom Penh,Oudong,Kampong Tralach,Silk Island,Angkor Ban,Kampong Cham,Siem Reap+8 more
- Age Range
- Ages 12+
- Ship
- AmaDara
- Operated in
- English
- Operator
- AmaWaterways
6% Off- From
- US$2,899per person+$280 upfront costs
Price based on Private Double Room- Booking needs min. 2 travelers
The Mekong in a different way - Between adventure and must-seesites (port-to-port cruise) (14 destinations)
- Duration
- 9 days
- Destinations
- Ho Chi Minh City, My Tho, Thoi Son Island, Cai Be, Sa Dec,Chau Doc,Vinh Xuong,Phnom Penh,Kampong Tralach,Oudong,Kompong Chhnang,Kampong Cham,Koh Chen,Siem Reap+9 more
- Age Range
- All Ages Welcome
- River
- Mekong
- Operated in
- English
- Operator
- CroisiEurope River Cruises
6% Off- From
- US$1,945per person
Price based on Private Double Room
The Mekong in a different way - Between adventure and must-seesites (19 destinations)
4.8 (2 traveler reviews)- Duration
- 11 days
- Destinations
- Ho Chi Minh City, My Tho, Thoi Son Island, Cai Be, Sa Dec,Chau Doc,Vinh Xuong,Phnom Penh,Kampong Tralach,Oudong,Kampong Cham,Kompong Chhnang,Koh Chen,Siem Reap,Angkor Wat,Tonle Sap Lake+11 more
- Age Range
- All Ages Welcome
- River
- Mekong
- Operated in
- English
- Operator
- CroisiEurope River Cruises
6% Off- From
- US$2,304per person
Price based on Private Double Room
The Mekong in a different way - Between adventure and must-seesites (11 destinations)
- Duration
- 9 days
- Destinations
- Ho Chi Minh City, My Tho, Cai Be, Sa Dec, Chau Doc,Phnom Penh,Kampong Tralach,Oudong,Kampong Chhnang,Koh Chen,Siem Reap+6 more
- Age Range
- All Ages Welcome
- River
- Mekong
- Operated in
- English
- Operator
- CroisiEurope River Cruises
6% Off- From
- US$1,754per person
Price based on Private Double Room
7-night Mekong Upstream Vietnam Cambodia on Mekong Navigator
5.0 (4 traveler reviews)"Great tour with nice food and friendly people."
- Duration
- 8 days
- Destinations
- Ho Chi Minh City, My Tho, Cai Be, Sa Dec, Cu Lao Gieng,Phnom Penh,Kampong Cham,Siem Reap+3 more
- Age Range
- Ages 12+
- Ship
- Mekong Navigator
- River
- Mekong
- Operated in
- English, German
- Operator
- Lotus Cruises
6% Off- From
- US$3,233per person
Price based on Private Double Room
The Mekong in a different way - Between adventure and must-seesites (port-to-port cruise) (17 destinations)
4.8 (2 traveler reviews)- Duration
- 11 days
- Destinations
- Ho Chi Minh City, My Tho, Thoi Son Island, Cai Be, Sa Dec,Chau Doc,Phnom Penh,Kampong Tralach,Oudong,Kompong Chhnang,Kampong Chhnang,Koh Chen,Siem Reap,Angkor Wat,Tonle Sap Lake+10 more
- Age Range
- All Ages Welcome
- River
- Mekong
- Operated in
- English
- Operator
- CroisiEurope River Cruises
6% Off- From
- US$2,670per person
Price based on Private Double Room
From the Mekong Delta to Siem Reap
5.0 (1 traveler review)- Duration
- 9 days
- Destinations
- Ho Chi Minh City, Cu Chi, My Tho, Vinh Long, Cai Be, Sa Dec,Chau Doc,Phnom Penh,Koh Chen,Kampong Tralach,Kompong Chhnang,Tonle Sap Lake,Siem Reap+7 more
- Age Range
- All Ages Welcome
- Ships
- RV IndochineRV Indochine II RV Lan Diep+2 ships
- River
- Mekong
- Operated in
- English
- Operator
- CroisiEurope River Cruises
6% Off- From
- US$2,019per person
Price based on Private Double Room
6% Off- From
- US$4,660per person+$596 upfront costs
Price based on Private Double Room
From the Mekong Delta to Siem Reap (port-to-port cruise) (13 destinations)
5.0 (1 traveler review)- Duration
- 9 days
- Destinations
- Ho Chi Minh City, Cu Chi, My Tho, Vinh Long, Cai Be, Sa Dec,Chau Doc,Phnom Penh,Koh Chen,Kampong Tralach,Kompong Chhnang,Tonle Sap Lake,Siem Reap+7 more
- Age Range
- All Ages Welcome
- Ships
- RV IndochineRV Indochine II RV Lan Diep+2 ships
- River
- Mekong
- Operated in
- English
- Operator
- CroisiEurope River Cruises
25% Off- From $2,315
- US$1,736per person
Price based on Private Double Room
