3-Week South America Tour Packages
Imagine South America in three week. Try a Machu Picchu trek, Buenos Aires tango, Iguazu Falls, Rio's Christ statue, and visit the Amazon rainforest. Take in Peru, Argentina, Brazil, maybe Chile or Ecuador. Andean peaks to tropical coasts, colonial cities to jungle lodges. Continent's contrasts hit different, with incredible diversity packed in.
Insider tips: Recommended 3-week South America tour itineraries
Compiled by

NinaSouth America travel expert at TourRadar
21 Day South America Itinerary, incl. Rio de Janeiro and Machu Picchu
A grand 21-day tour spans 12 South American cities, from Copacabana Beach to Machu Picchu. The luxury Titicaca Express train, 5 domestic flights, and visits to Cusco's Q'oricancha Temple await. Premium hotels complement visits to Iguazu Falls, Buenos Aires, and Sacred Valley.

- Days 1-3
Rio de Janeiro, Brazil
Arrive at Galeão Airport before 2 PM to avoid Rio's heavy afternoon traffic. On your first night take a walk along Copacabana Beach's black and white promenade. For the next two days focus on Rio's main attractions early in the day. Get the first cable car to Sugarloaf Mountain at 8 AM for the best city views without crowds. Visit Christ the Redeemer by taking the cog train through Tijuca National Park. Bring a light jacket since mornings at the top can be cooler than you might expect.

- Days 4-5
Iguazu Falls
Take a 2-hour flight to Foz do Iguaçu. You'll want to see these falls from both the Brazilian and Argentine sides. Start on the Brazilian side for sweeping views then spend a full day exploring the Argentine side's walkways. Bring a waterproof bag to protect your camera from the heavy spray at Devil's Throat. A natural gas train runs to the falls every 30 minutes.

- Days 6-7
Buenos Aires, Argentina
Fly in during the morning and get settled in Argentina's capital. Visit the colorful La Boca district before 5 PM for safety. You can take your time with dinner since most locals eat after 9 PM. Book your tango shows ahead of time as good venues fill up fast. For evening walks stick to the upscale Recoleta area.

- Days 8-12
Bolivia's Highlights
Flying to Sucre through Santa Cruz brings your first real altitude change. Take things slow when you arrive. The historic center is easy to walk but you'll need good shoes for the steep cobblestone streets. La Paz sits at 11,942 feet so give yourself a full day to adjust before serious sightseeing. The Witches' Market is interesting but ask before taking photos.

- Days 13-14
Lake Titicaca Region
- Days 15-19
Cusco & Machu Picchu, Peru
Take the luxury train from Puno to Cusco for great Andean views but know that rail strikes can happen. Stay in Cusco's San Blas neighborhood for its charm and good location. For Machu Picchu take the first 5:30 AM bus from Aguas Calientes to see the site before the crowds. Book Huayna Picchu permits months ahead since they only allow 400 people daily.

- Days 20-21
Lima
Southern Divide
A cultural immersion from Lima to Santiago spans 21 days. Machu Picchu, Lake Titicaca's Uros islands, and the Atacama Desert's Valley of the Moon captivate visitors. Local guesthouses and the unique Jukil Community Lodge provide authentic experiences.

Lima Peru
357 miCusco Peru
51 miRainbow Mountain Peru
51 miCusco Peru
14 miSacred Valley Peru
13 miOllantaytambo Peru
18 miAguas Calientes Peru
5 miShow 16 more
Machu Picchu Peru
5 miAguas Calientes Peru
5 miMachu Picchu Peru
40 miCusco Peru
51 miRainbow Mountain Peru
51 miCusco Peru
207 miPuno Peru
42 miLake Titicaca Bolivia
19 miTaquile Island Peru
5 miUros Reed Islands Peru
17 miPuno Peru
132 miLa Paz Bolivia
257 miSucre Bolivia
52 miPotosi Bolivia
90 miUyuni Bolivia
54 miUyuni Salt Flat Bolivia
142 miRed Lagoon (Laguna Colorada) Bolivia
134 miUyuni Bolivia
190 miSan Pedro De Atacama Chile
5 miValle de la Luna Chile
742 miSantiago Chile
21 Day South America Itinerary, incl. Machu Picchu and Rio de Janeiro
Rich cultural heritage spans 17 cities across 5 countries over 21 days. UNESCO wonders from Machu Picchu to Iguazu Falls complement natural spectacles at Uyuni Salt Flats and Atacama Desert. Four-star accommodations and guided tours create comfortable adventures.

- Days 1-2
Lima
Begin your South American adventure in Peru's capital. Spend time exploring the UNESCO colonial center, including Plaza Mayor and San Francisco's catacombs. Book a hotel in Miraflores, an upscale district with ocean views and safe nighttime walking. Your second day features a Peruvian paso horse show at Hacienda Mamacona.

- Days 3-4
Cusco & Sacred Valley
Book a morning flight to Cusco between 9-10am to avoid afternoon mountain winds. Use your first day for gentle acclimatization by exploring the main plaza and Koricancha temple. Next day, visit the Sacred Valley and Pisac market early morning before the crowds arrive. Stay overnight in Ollantaytambo before Machu Picchu.

- Day 5
Machu Picchu
- Days 6-7
Puno & Lake Titicaca
- Days 8-9
La Paz
- Days 10-11
Uyuni Salt Flats
- Days 12-13
Atacama Desert
- Days 14-15
Santiago & Buenos Aires
- Days 16-17
Iguazu Falls
- Days 18-21
Rio de Janeiro
What people love about 3-week South America tours
- Southern Divide
Amazing tour. South America is such a beautiful and unique place. Our tour guide was really helpful and easy to come to with questions and concerns. Highly recommended
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