City & Culture Tours & Trips in Italy and Spain
The most comprehensive tours blending Spain and Italy run for 13-14 days, taking cultural enthusiasts well beyond tourist hotspots. Early morning access to Granada's Alhambra Palace and cable car rides up to medieval Orvieto give you special perspectives, while hands-on experiences make these journeys distinctive. You'll master pesto-making in Cinque Terre, join local mushroom hunts through the Pyrenees, and experience grape harvests in French wine country. TourRadar customers often mention how these tours balance expert guidance at major sites, like Rome's Colosseum, with genuine local encounters at family wineries across Tuscany and Rioja. For those with tighter schedules, the 9-day Barcelona to Rome route delivers cultural depth through small group market visits and walks through ancient neighborhoods. Train travel between destinations creates natural chances to meet locals and discover those special places that don't make it into standard guidebooks.
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10 best City & Culture Italy and Spain tour packages
Compiled by

NadineItaly and Spain travel expert at TourRadar
- Enjoy Andalusia, Mediterranean Coast and Classic Italy
- Barcelona to Rome Quest (Hostels, Age 18-22)
- Barcelona to Rome Quest (Hotels, Summer From Apr '27, Classic)
- Cultures of the Mediterranean Barcelona to Civitavecchia
- Icons of Italy & the French Riviera - Cruise & Land Journey
- Highlights of Spain, Morocco & Italy
- Discover Timeless Horizons: Tenerife to Italy
- Jewels of the Mediterranean
- Barcelona to Rome Quest (Hotels, Winter From Apr '27, Classic)
- Catalonia & Mediterranean Islands - Cruise & Land Journey
Duration 15 days Destinations Spain, Italy, Vatican City (Holy See) Age Range Ages 18+ Operator Remaz Tours GmbH From
- US$6,057
Duration 12 days Destinations Spain, Italy, Tunisia, Malta, Vatican City (Holy See) Age Range Ages 12+ Operator Emerald Cruises From $10,595
27% off- US$7,738
Duration 19 days Destinations Italy, Monaco, France, Spain Age Range Ages 18+ Operator Scenic Luxury Cruises & Tours From $26,350
9% off- US$24,103
Duration 11 days Destinations Spain, Morocco, Gibraltar, France, Italy Age Range Ages 12+ Operator Emerald Cruises From $10,545
14% off- US$9,071
Duration 18 days Destinations Spain, Morocco, Gibraltar, France, Italy Age Range Ages 12+ Operator Emerald Cruises From $18,040
17% off- US$14,897
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