City & Culture Tours & Trips in Italy and Spain
The most comprehensive tours blending Spain and Italy run for 13-14 days, taking cultural enthusiasts well beyond tourist hotspots. Early morning access to Granada's Alhambra Palace and cable car rides up to medieval Orvieto give you special perspectives, while hands-on experiences make these journeys distinctive. You'll master pesto-making in Cinque Terre, join local mushroom hunts through the Pyrenees, and experience grape harvests in French wine country. TourRadar customers often mention how these tours balance expert guidance at major sites, like Rome's Colosseum, with genuine local encounters at family wineries across Tuscany and Rioja. For those with tighter schedules, the 9-day Barcelona to Rome route delivers cultural depth through small group market visits and walks through ancient neighborhoods. Train travel between destinations creates natural chances to meet locals and discover those special places that don't make it into standard guidebooks.
- Choose from 26 Italy and Spain tours
- 350+ verified reviews from TourRadar travelers
- 24/7 customer support
- J
Julie • traveled in December
We had an amazing time. Wasn't expecting to fall in love with Spain, what a beautiful country!. Italy was so special. Rome, the history and meaning, so emotional and overwhelming. It rained in Monaco unfortunately but we'll just have to go back. The rest of the time in France was beautiful. We had a great group, met lifelong friends for sure!. Our TD was different from other TDs i've had, he (Gerry) is from another planet for sure, operates on another level. What an amazing person. I only hope I'm half as good at my job as he is.
Mediterranean Highlights
10 best City & Culture Italy and Spain tour packages
Compiled by

NadineItaly and Spain travel expert at TourRadar
- From Gelato to Gaudi: Italy & Spain Journey
- Icons of Italy & Mediterranean Rivieras - Cruise & Land Journey
- Mediterranean Rivieras
- Highlights of Spain, Morocco & Italy
- Enjoy Andalusia, Mediterranean Coast and Classic Italy
- Icons of Italy & the French Riviera - Cruise & Land Journey
- Mediterranean Odyssey with a Taste of Italy - Cruise & Land Journey
- Mediterranean Highlights: Sardinia, Ibiza & the Riviera
- Idyllic Islands of the Mediterranean 2028 - 12 Days (from Barcelona to Rome)
- Icons of Italy & Mediterranean Islands - Cruise & Land Journey
Duration 17 days Destinations Italy, Vatican City (Holy See), Spain Age Range All Ages Welcome Operator Omega Tours From
- US$4,718
Duration 18 days Destinations Italy, France, Monaco, Spain Age Range Ages 18+ Operator Scenic Luxury Cruises & Tours From
- US$24,850
Duration 12 days Destinations Italy, France, Spain, Morocco, Portugal Age Range Ages 12+ Operator Emerald Cruises From $9,645
19% Off- US$7,790You save $1,855
Duration 11 days Destinations Spain, Morocco, Gibraltar, France, Italy Age Range Ages 12+ Operator Emerald Cruises From $10,545
14% Off- US$9,071You save $1,474
Duration 15 days Destinations Spain, Italy, Vatican City (Holy See) Age Range Ages 18+ Operator Remaz Tours GmbH From
14% Off- US$6,187
Duration 19 days Destinations Italy, Monaco, France, Spain Age Range Ages 18+ Operator Scenic Luxury Cruises & Tours From
14% Off- US$26,350
Duration 23 days Destinations Spain, France, Monaco, Italy Age Range Ages 12+ Operator Scenic Luxury Cruises & Tours From $29,915
15% Off- US$25,414You save $4,501
















