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Mexico City to Panama City Tours

Find tours that start in Mexico City, and then finish in Panama City in Panama. Trips from Mexico City to Panama City are most popular in June, with the most tours doing this route then.

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9 Mexico City to Panama City trips

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  • Grand Mexico & Panama

    49 day adventure tour through Mexico City, Puebla, Oaxaca and 22 other destinations in 7 different countries

    destinations
    26 destinations in 7 countries
    starts/ ends in
    Mexico City / Panama City
    age range
    18 to 65 year olds
    accommodation
    Hotel, Berth / Cabin, Sleeper Bus+1 more
    transport
    Boat, Local Transport, Private Vehicle, Plane+2 more
    operator
    Tucan Travel
    Days
    49
    Our saving
    $189
    From
    US $ 4,530
    • +$590 local payments
    days
    49
    $92 per day
    2 Jun 2018 3 spaces left
    21 Jul 2018 7 spaces left
    View MoreGetDownload Brochure
  • Complete Central America

    65 day discovery tour through Mexico City, Puebla, Oaxaca and 53 other destinations in 9 different countries

    destinations
    66 destinations in 9 countries
    starts/ ends in
    Mexico City / Panama City
    age range
    15 to 99 year olds
    accommodation
    Hotel, Home-stay, Camping, Lodge, Guesthouse, Sleeper Bus+3 more
    transport
    Coach / Bus, Boat, Local Transport, Private Vehicle, Ferry+3 more
    operator
    Intrepid Travel
    -14%
    Days
    65
    Our saving
    $855
    From
    $6,290
    US $ 5,435
    days
    65
    $84 per day
    19 May 2018 1 space left
    30 Jun 2018 3 spaces left
    View MoreGetDownload Brochure
  • Pan American between Mexico City and Panama City (Panama City to Mexico City)

    55 day overland truck tour through Mexico City, Oaxaca, San Cristobal and 32 other destinations in 8 different countries

    destinations
    35 destinations in 8 countries
    starts/ ends in
    Mexico City / Panama City
    age range
    18 to 99 year olds
    accommodation
    Hotel, Camping
    transport
    Overland Truck, Boat, Plane+1 more
    operator
    Dragoman
    -23%
    Days
    55
    Our saving
    $1,092
    From
    $4,705
    US $ 3,613
    • +$1,510 local payments
    days
    55
    $66 per day
    9 Apr 2019 10+ spaces left
    View MoreGetDownload Brochure
  • Vida Loca Ways (from Mexico City)

    49 day hop on/off tour through Mexico City, Teotihuacan, Oaxaca and 35 other destinations in 7 different countries

    destinations
    46 destinations in 7 countries
    starts/ ends in
    Mexico City / Panama City
    age range
    18 to 99 year olds
    operator
    Bamba Experience
    Days
    49
    Our saving
    $113
    From
    US $ 2,716
    days
    49
    $55 per day
    28 Apr 2018 10 spaces left
    29 Apr 2018 10 spaces left
    View MoreGetDownload Brochure
  • Zorro Ways (from Mexico City)

    39 day hop on/off tour through Mexico City, Teotihuacan, Oaxaca and 23 other destinations in 6 different countries

    destinations
    33 destinations in 6 countries
    starts/ ends in
    Mexico City / Panama City
    age range
    18 to 99 year olds
    accommodation
    Home-stay
    operator
    Bamba Experience
    Days
    39
    Our saving
    $88
    From
    US $ 2,111
    days
    39
    $54 per day
    28 Apr 2018 10 spaces left
    29 Apr 2018 10 spaces left
    View MoreGetDownload Brochure
  • Ultimate Central America

    58 day in-depth cultural tour through Mexico City, Teotihuacan, Puebla and 29 other destinations in 7 different countries

    destinations
    34 destinations in 7 countries
    starts/ ends in
    Mexico City / Panama City
    age range
    15 to 70 year olds
    accommodation
    Hotel, Home-stay, Camping, Lodge, Sleeper Bus+2 more
    transport
    Coach / Bus, Boat, Local Transport, Mini-coach, Ferry+3 more
    operator
    Intrepid Travel
    -14%
    Days
    58
    Our saving
    $708
    From
    $5,205
    US $ 4,498
    days
    58
    $78 per day
    23 Jun 2018 2 spaces left
    14 Jul 2018 7 spaces left
    View MoreGetDownload Brochure
  • Guacamole Ways (from Mexico City)

    47 day discovery tour through Mexico City, Teotihuacan, Oaxaca and 34 other destinations in 7 different countries

    destinations
    44 destinations in 7 countries
    starts/ ends in
    Mexico City / Panama City
    age range
    18 to 99 year olds
    operator
    Bamba Experience
    Days
    47
    Our saving
    $118
    From
    US $ 2,821
    days
    47
    $60 per day
    28 Apr 2018 10 spaces left
    29 Apr 2018 10 spaces left
    View MoreGetDownload Brochure
  • Sofia Ways (from Mexico City)

    38 day hop on/off tour through Mexico City, Teotihuacan, Oaxaca and 22 other destinations in 6 different countries

    destinations
    30 destinations in 6 countries
    starts/ ends in
    Mexico City / Panama City
    age range
    18 to 99 year olds
    accommodation
    Home-stay
    operator
    Bamba Experience
    Days
    38
    Our saving
    $93
    From
    US $ 2,221
    days
    38
    $58 per day
    28 Apr 2018 10 spaces left
    29 Apr 2018 10 spaces left
    View MoreGetDownload Brochure
  • Limonada Ways (from Mexico City)

    39 day hop on/off tour through Mexico City, Teotihuacan, Oaxaca and 25 other destinations in 7 different countries

    destinations
    34 destinations in 7 countries
    starts/ ends in
    Mexico City / Panama City
    age range
    18 to 99 year olds
    operator
    Bamba Experience
    Days
    39
    Our saving
    $94
    From
    US $ 2,260
    days
    39
    $58 per day
    28 Apr 2018 10 spaces left
    29 Apr 2018 10 spaces left
    View MoreGetDownload Brochure